C957T
The C957T
Dopamine D2 receptor expression is increased among individuals who carry the 957T allele compared to individuals who carry the 957C allele (in contrast to the original article publication, which has since been corrected).[1] [2]
Behaviours associated with the C/C genotype of the C957T polymorphism
- schizophrenia[3][4]
- diminished working memory ability[5]
- altered response to nicotine[6]
- reward related impulsivity[7]
- sucrose addiction[8]
- altered susceptibility to iatrogenic tardive dyskinesia[9][10]
- altered fear conditioning[11]
- dissocial personality disorder[12]
- posttraumatic stress disorder[13]
Given that the C/C genotype has been associated with dissocial personality disorder one may infer that this genotype may also be associated with all four
cluster B personality disorders
. This hypothesis, however, has not been tested.
Rapid screening of the C957T and the TaqIA polymorphisms
Given the importance of the C957T and TaqIA polymorphisms for the diagnosis and treatment of psychological disorder, a rapid screening protocol for these genes has been developed.[14] Since the DRD2 1101A allele nulls the effects of the 957T allele,[15] screens for the 957C allele which ignore the 1101A allele can sometimes lead to false negatives.
References
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- . Retrieved 16 March 2023.
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- ^ Cambridge Journals Online - Abstract
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- PMID 19900188.
- PMID 18669994.
- S2CID 1698669.>T polymorphism is associated with Posttraumatic Stress Disorder in war veterans - Voisey - 2008 - Depression and Anxiety - Wiley Online Library]
- PMID 20099571.
- PMID 12554675.