Calcifying epithelial odontogenic tumor
The calcifying epithelial odontogenic tumor (CEOT), also known as a Pindborg tumor, is an odontogenic
Types
Intraosseous tumors (tumors within the bone) are more common (94%) than extraosseous tumors (6%).
Clinical features
Clinically it has two types, the central and the peripheral. The central type of the CEOT occurs in individuals ranging in age from 20 to 60 years. Two-thirds of the lesions are in jaws, more commonly in the molar area with a tendency to occur in the pre-molar areas.[2] It appears clinically to be a slowly enlarging painless mass. In the maxilla it can cause proptosis, epistaxis and nasal airway obstruction. The peripheral type is commonly found in the anterior region of the maxilla and occurs as a soft tissue swelling.
Histology
Histopathology will reveal prominent intercellular bridges and nuclear changes such as pleomorphism, hyperchromatism and prominent nucleoli. The mitotic figures are rare. Spread throughout the epithelium and connective tissue are spherical amorphous calcifications.
Variants include the clear cell CCEOT; whose cells have clear cytoplasms. The incidence is low, with 15 cases of CCEOT reported.[2] However, another study has indicated that approximately 8% of CEOTs contain clear cells.[3]
There is one case reported in the literature of a 15-year-old white male with a true cystic variant of CEOT.[4]
Recurrence
The recurrence rate is 10-15%.[5] Franklin and Pindborg reported a recurrence rate of 14%.[6] It is considered to have a recurrence rate much lower than that of ameloblastoma. Malignant metastasis has been reported.[1]
See also
- ODAM (gene)
- Proteopathy
- Tooth development
References
- Zahid, Arsalan from Contemporary Oral and Maxillofacial Pathology
- Kahn, Michael A. Basic Oral and Maxillofacial Pathology. Volume 1. 2001.