Capsugel

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Coordinates: 40°46′18″N 74°30′13″W / 40.77165°N 74.50366°W / 40.77165; -74.50366
Source: Wikipedia, the free encyclopedia.
Capsugel, Inc.
Lonza Group
Websitecapsugel.com

Capsugel is a company that manufactures and sells two-piece hard gelatin drug capsules.[3]: 703  Capsugel also sells equipment for filling empty and liquid capsules, as well as equipment for sealing liquid capsules.

History

Capsugel was founded in the 1960s as a division of

Warner Lambert, which was acquired by Pfizer in 2000. On 1 August 2011, Pfizer sold Capsugel to global investment firm Kohlberg Kravis Roberts for $2.38 billion.[2][4] In July 2017, the Lonza Group completed the acquisition of Capsugel for $5.5 billion from Kohlberg Kravis Roberts.[1][5] In 1987, while a subsidiary of Warner Lambert, the firm was one of only five pharmaceutical joint ventures in China, the joint venture firm being Suzhou Capsugel Ltd.[6]

According to one source, Capsugel originated technology for the production of hard shell capsules from starch.[7]

Executive history

Charles Hoover was promoted to President of the company in 1989; he had previously served as the general manager of the company's largest manufacturing facility and had introduced quality improvement to the company starting in 1982.[3]: 706–707  During his tenure as President, he introduced a company-wide focus on statistical process control.[3]: 707  By 2016, the company's President and chief executive officer (CEO) was Guido Driesen.[1]

Products

Coni-Snap

Coni-Snap capsules are a standard two-part hard gelatin capsule that are usually filled with either

powder or granules (though they can also be filled with pellets, tablets, pastes, or liquids). Coni-Snap capsules are distributed in multiple sizes and colors.[8]

The body section of the Coni-Snap design has a tapered rim to facilitate encapsulation on high-speed capsule-filling machines. It has a dual snap-ring locking system that provides an initial attachment prior to capsule filling and a final closure of the filled capsule. The Coni-Snap design also includes air vents to avoid unwanted

air compression
within the capsule during high speed filling.

DBcaps

DBcaps capsules are a line of capsules designed specifically for use in

variability in the study. The DBcap capsule design also incorporates a locking design to prevent the participants from opening the capsules and breaking the blind.[9]

Vcaps

Vcaps capsules are a two-piece capsule made of

halaal.[10]

Licaps

Licaps capsules are two-piece gelatin or hydroxypropyl methylcellulose capsules designed specifically for containing liquids or semi-solids. Licaps can be used when drugs' ingredients are more stable as a liquid, such as in

dietary supplements.[11]

Facilities

As of 1991, the company's four largest manufacturing plants were located in the United States (Greenwood, South Carolina),[3]: 709  Belgium, France and Japan; smaller manufacturing units were located in Britain, Mexico, Italy, Thailand, Brazil and China.[3]: 704 

Intellectual property

European patent EP2844297 "Aqueous Dispersions of Controlled Release Polymers and Shells and Capsules Thereof", filed in 2013, was granted to the Belgium unit of Capsugel in 2018 with an anticipated expiry in 2033.[12][13]

European patent EP2844296 "Aqueous Dispersions of Hydroxypropyl Methylcellulose Acetate Succinate (HPMCAS)", filed in 2013, was granted to the Belgium unit of Capsugel in 2019 with an anticipated expiry in 2033.[14][15]

Notes

  1. ^ a b c d "Lonza to Acquire Capsugel to Create Leading Integrated Solutions Provider to the Global Pharma and Consumer Healthcare Industries". New Jersey Business. Trenton, New Jersey: New Jersey Business & Industry Association. December 15, 2016. Retrieved 21 Jan 2020.
  2. ^ a b c Krauskopf, Lewis (April 4, 2011). "Pfizer selling Capsugel to KKR for $2.38 billion". Reuters. Archived from the original on January 13, 2020. Retrieved 21 Jan 2020.
  3. ^
    ISBN 0-89930-600-4
    – via Internet Archive. Note: two of the four authors of Chapter 28 were Capsugel employees. Also cited is "Summary and Implications (Chapter 34), by the editors of the book.
  4. ^ Bonds, Shannon; Jack, Andrew (4 April 2011). "KKR to buy Pfizer's capsule unit for $2.4bn". The Financial Times.
  5. ^ "Lonza Completes Acquisition of Capsugel to Create Leading Integrated Solutions Provider to the Global Pharma and Consumer Healthcare Industries". Media Center (Press release). Lonza. July 6, 2017. Retrieved 20 Jan 2020.
  6. LCCN 89-60187
    – via Internet Archive.
  7. ISBN 0-8247-0674-9 – via Internet Archive. Note: Source lacks page numbers; the cited item here comes from page 2 of the cited chapter.Open access icon
  8. ^ "Coni-Snap Hard Gelatin Capsules". Capsules. Capsugel. Archived from the original on May 27, 2011. Retrieved 28 Dec 2012.[self-published source]
  9. ^ "DBcaps Over-encapsulation Capsules". Capsules. Capsugel. Archived from the original on May 27, 2011. Retrieved 28 Dec 2012.[self-published source]
  10. ^ "Vcaps & Vcaps Plus Plant-based Capsules". Capsules. Capsugel. Archived from the original on December 26, 2012. Retrieved 28 Dec 2012.[self-published source]
  11. ^ "Licaps Liquid-filled Capsules". Capsules. Capsugel. Archived from the original on May 27, 2011. Retrieved 28 Dec 2012.[self-published source]
  12. ^ "Global Dossier". US Patent & Trademark Office. EP 13711002. Retrieved 20 Jan 2020.
  13. ^ "EP2844297A1 - Aqueous dispersions of controlled release polymers and shells and capsules thereof". Google Patents. Application EP13711002.9A events. Retrieved 20 Jan 2020.
  14. ^ "Global Dossier". US Patent & Trademark Office. EP 13709435. Retrieved 20 Jan 2020.
  15. ^ "EP2844296A1 - Aqueous dispersions of hydroxypropyl methylcellulose acetate succinate (hpmcas)". Google Patents. Application EP13709435.5A events. Retrieved 20 Jan 2020.

Further reading

40°46′18″N 74°30′13″W / 40.77165°N 74.50366°W / 40.77165; -74.50366

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