Disufenton sodium

Source: Wikipedia, the free encyclopedia.
Disufenton sodium
Clinical data
ATC code
  • none
Identifiers
  • Disodium 4-[(Z)-(tert-butyl-oxidoazaniumylidene)methyl]benzene-1,3-disulfonate
JSmol)
  • CC(C)(C)[N+]([O-])=Cc1ccc(cc1S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+]
  • InChI=1S/C11H15NO7S2.2Na/c1-11(2,3)12(13)7-8-4-5-9(20(14,15)16)6-10(8)21(17,18)19;;/h4-7H,1-3H3,(H,14,15,16)(H,17,18,19);;/q;2*+1/p-2 ☒N
  • Key:XLZOVRYBVCMCGL-UHFFFAOYSA-L ☒N
 ☒NcheckY (what is this?)  (verify)

Disufenton sodium (Cerovive, OKN-007, NXY-059, HPN-07)[1] is a free radical trapping nitrone-based antioxidant compound that has been under development for several medical conditions.[2][3]

Chemistry

Disufenton sodium is the disulfonyl derivative of the neuroprotective nitrone spin trap phenylbutylnitrone or "PBN". PBN and its derivatives hydrolyze and oxidize in vitro to form respectively MNP-OH (AKA, NtBHA) and its parent spin-trap MNP.

Research

Disufenton sodium was under development at the drug company AstraZeneca. A 2005 phase-3 clinical trial[4][5] called "SAINT-1" reported some efficacy in the acute treatment of ischemia injury due to stroke. However, a 2006 attempt to repeat this trial indicated no significant activity. After ruling out other causes, the authors tentatively attributed the positive results in the first trial to "chance".[4] AstraZeneca then terminated the development programme.[6]

Disufenton sodium has been researched as a potential treatment for use in brain tumors and cancers, including

diffuse intrinsic pontine glioma (DIPG)[7][8] and glioblastoma.[9][10]

A compound (NHPN-1010) containing a combination of disufenton sodium and acetylcysteine has been researched as a potential treatment for tinnitus and hearing loss.[11][12][13][14]

References

  1. PMID 34539349
    .
  2. S2CID 36633423
    .
  3. PMID 26771008
    .
  4. ^
    PMID 16467546
    .
  5. PMID 17068304
    .
  6. ^ "Renovis: Press Release". Archived from the original on October 28, 2006.
  7. PMID 33168005
    .
  8. ^ "FDA grants fast track status to OKN-007 for diffuse intrinsic pontine glioma". Healio. March 3, 2021. Retrieved February 5, 2022.
  9. S2CID 219772612
    .
  10. PMID 34910361
    .
  11. PMID 33411811
    .
  12. S2CID 208621727
    .
  13. ^ "Congressionally Directed Medical Research Programs (CDMRP) Search Awards". Congressionally Directed Medical Research Programs. Retrieved February 5, 2022.
  14. ^ Martin B (July 27, 2020). "Hough Ear Institute receives $300K grant to support research treatments for hearing loss". KOKH. Retrieved February 5, 2022.

Further reading
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