Duojia Pan

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Duojia Pan (Chinese: 潘多加) is a Chinese-American developmental biologist at the University of Texas Southwestern Medical Center, where he is Fouad A. and Val Imm Bashour Distinguished Professor of Physiology, chairman of the department of physiology, and investigator of the Howard Hughes Medical Institute (HHMI). His research is focused on molecular mechanisms of growth control and tissue homeostasis and their implications in human disease.[1]

Biography

Pan was born in

Howard Hughes Medical Investigator (2008), a Fellow of the American Association for the Advancement of Science (2012), and received the Paul Marks Prize for Cancer Research (2013). In 2016, Pan returned to UT Southwestern Medical Center as chair of the department of physiology.[2] He received the Passano Award [3] from Passano Foundation in 2022 and was elected to the National Academy of Sciences
in 2023.

Research

Pan is best known for his pioneering work elucidating the

oncoproteins driving tumor growth.[9][10]

Besides the Hippo pathway, Pan also contributed to the understanding of other developmental signaling pathways. As a postdoctoral fellow, Pan identified cAMP-dependent

tumor suppressor genes to Rheb[13] and mTOR signaling.[14] This discovery provided the molecular basis for using mTOR inhibitors in the treatment of tuberous sclerosis.[15]

References

  1. ^ "Duojia Pan, Ph.D." University of Texas Southwestern Medical Center.
  2. ^ "CV of Duojia Pan" (PDF). University of Texas Southwestern Medical Center.
  3. ^ "RECIPIENTS OF THE PASSANO LAUREATE AND PHYSICIAN SCIENTIST AWARDS".
  4. ^ Wu, S., Huang, J., Dong, J., and Pan, D. (2003). hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell 114, 445-456.
  5. ^ Wu, S., Liu, Y., Zheng, Y., Dong, J., and Pan, D. (2008). The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway. Developmental cell 14, 388-398.
  6. ^ Koontz, L.M., Liu-Chittenden, Y., Yin, F., Zheng, Y., Yu, J., Huang, B., Chen, Q., Wu, S., and Pan, D. (2013). The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression. Developmental cell 25, 388-401.
  7. ^ Huang, J., Wu, S., Barrera, J., Matthews, K., and Pan, D. (2005). The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell 122, 421-434.
  8. ^ Dong, J., Feldmann, G., Huang, J., Wu, S., Zhang, N., Comerford, S.A., Gayyed, M.F., Anders, R.A., Maitra, A., and Pan, D. (2007). Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell 130, 1120-1133.
  9. ^ Zhang, N., Bai, H., David, K.K., Dong, J., Zheng, Y., Cai, J., Giovannini, M., Liu, P., Anders, R.A., and Pan, D. (2010). The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. Developmental cell 19, 27-38.
  10. ^ Cai, J., Zhang, N., Zheng, Y., de Wilde, R.F., Maitra, A., and Pan, D. (2010). The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. Genes & development 24, 2383-2388.
  11. ^ Pan, D., and Rubin, G.M. (1995). cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs. Cell 80, 543-552.
  12. ^ Pan, D., and Rubin, G.M. (1997). Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell 90, 271-280.
  13. ^ Zhang, Y., Gao, X.S., Saucedo, L.J., Ru, B.G., Edgar, B.A., and Pan, D.J. (2003). Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nature cell biology 5, 578-581.
  14. ^ Gao, X., Zhang, Y., Arrazola, P., Hino, O., Kobayashi, T., Yeung, R.S., Ru, B., and Pan, D. (2002). Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nature cell biology 4, 699-704.
  15. ^ Huang, J., and Manning, B.D. (2008). The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. The Biochemical journal 412, 179-190.