EEA1

EEA1
	Gene ontology
Molecular function	protein homodimerization activity; zinc ion binding; metal ion binding; calmodulin binding; GTP-dependent protein binding; 1-phosphatidylinositol binding; protein binding; nucleic acid binding;
Cellular component	cytoplasm; recycling endosome; cytosol; endosome; early endosome membrane; membrane; axonal spine; serine-pyruvate aminotransferase complex; early endosome; extrinsic component of plasma membrane; extracellular exosome; cytoplasmic vesicle; presynapse; synapse;
Biological process	endocytosis; early endosome to late endosome transport; synaptic vesicle to endosome fusion; vesicle fusion;
	Sources:Amigo / QuickGO

Ensembl


ENSG00000102189


ENSMUSG00000036499

UniProt


Q15075


Q8BL66

RefSeq (mRNA)


NM_003566


NM_001001932

RefSeq (protein)


NP_003557


NP_001001932

Location (UCSC)

Chr 12: 92.77 – 92.93 Mb

Chr 10: 95.78 – 95.88 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

The gene EEA1 encodes for the 1400 amino acid protein, Early Endosome Antigen 1.

EEA1 localizes exclusively to early

SNAREs such as N-ethylmaleimide sensitive fusion protein

, bringing the endosomes physically closer and ultimately resulting in the fusion and delivery of endosomal cargo.

Function

EEA1 is a RAB5A effector protein which binds via an N-terminal zinc finger domain and is required for fusion of early and late endosomes and for sorting at the early endosome level.^[5]^[6]

EEA1 plays a role in endocytosis and is recruited by Rab5-GTP to endosomal membranes.^[7] EEA1 may be regulated through monoubiquination, affecting endosome fusion and trafficking.^[8] Ubiquitin selective segregase p97 may regulate EEA1's tethering ability, affecting its endosome trafficking and morphplogy.

Involvement in pathogenesis

Due to the proteins importance in vesicular trafficking, a number of intracellular bacteria prevent EEA1 recruitment to the vacuole. Mycobacterium tuberculosis is known to inhibit the recruitment of EEA1 to the phagosomal membrane through CamKII.^[9] Legionella pneumophila also prevents EEA1 recruitment through a currently unknown mechanism.^[10] The related pathogen Legionella longbeachae recruits EEA1 and appears to replicate within a modified early endosome.^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000102189 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036499 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
PMID 20534488
.

PMID 19487677
.

ISBN 978-0-12-374145-5
.

PMID 23701900
.

PMID 12626530
.

S2CID 205840762
.

S2CID 11318022
.

External links

early+endosome+antigen+1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Overview of all the structural information available in the PDB for UniProt: Q15075 (Early endosome antigen 1) at the PDBe-KB.

Retrieved from "https://en.wikipedia.org/w/index.php?title=EEA1&oldid=1209142983"

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000102189 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036499 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] PMID 20534488
.

[6] PMID 19487677
.

[7] ISBN 978-0-12-374145-5
.

[8] PMID 23701900
.

[9] PMID 12626530
.

[10] S2CID 205840762
.

[11] S2CID 11318022
.

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

Function

Involvement in pathogenesis

See also

References

External links