Eckhard Boles

Eckhard Boles (born September 4, 1963 in

Life and work

Eckhard Boles was born in 1963 in Altena in

Until 1995, he stayed at the TH Darmstadt as a post-doctoral fellow and worked on the function of fructose-2,6-bisphosphate in the glycolysis of baker's yeast. From 1996 to 2001 he worked as a scientific assistant (C1) at the Institute for Microbiology at the University of Düsseldorf; until 2000, he worked on his habilitation on glucose transport and metabolism in yeasts. He received his Venia Legendi in 2001 and remained as a senior assistant (C2) at the University of Düsseldorf until 2002. In 2002, he moved to the Goethe University in Frankfurt, where he was appointed to a chair as C3 Professor of Microbiology. Since November 2011 he has been W3 Professor of Microbiology with a focus on Physiology and Genetics of Lower Eukaryotes at the same institute.[2]

In the summer of 2007, Boles co-founded Butalco GmbH, Zug, Switzerland, together with

• the biotechnological production of butanol and aromatic compounds
• the biotechnological production of
  polyketides
• C5 technologies: Fermentation of
  pentoses
  with recombinant yeast cells
• Sugar uptake and human glucose transporters
• Synthetic
  organelles and channeling concepts

Bibliography (selection)

Eckhard Boles regularly publishes articles on his research activities in scientific journals. These are contributions to original research as well as review articles on central topics in molecular biology and biotechnology.^[6]

• E. Boles: Molekulargenetische und physiologische Untersuchungen zur Regulation des Kohlenhydratstoffwechsels in Glykolysemutanten der Hefe "Saccharomyces cerevisiae" / eingereicht von Eckhard Boles. Technische Hochschule Darmstadt, Dissertation 1994.
• R. Wieczorke, S. Krampe, T. Weierstall, K. Freidel, C.P. Hollenberg, E. Boles: Concurrent knock‐out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae. FEBS letters 464 (3), 1999; S. 123–128.
  doi:10.1016/S0014-5793(99)01698-1
• E. Boles, R. Krämer: Molecular Mechanisms Controlling Transmembrane Transport. Series Topics in Current Genetics, Vol 9, Springer Verlag, 2004.
  ISBN 978-3-540-21837-1
• D. Brat, E. Boles, B. Wiedemann: Functional expression of a bacterial xylose isomerase in Saccharomyces cerevisiae. Applied and Environmental Microbiology 75 (8), 2009; S. 2304–2311.
  doi:10.1128/AEM.02522-08
• C. Weber, A. Farwick, F. Benisch, D. Brat, H. Dietz, T. Subtil, E. Boles: Trends and challenges in the microbial production of lignocellulosic bioalcohol fuels. Applied Microbiology and Biotechnology 87 (4), 2010; S. 1303–1315.
  doi:10.1007/s00253-010-2707-z
• M. Gottardi, M. Reifenrath, E. Boles, J. Tripp: Pathway engineering for the production of heterologous aromatic chemicals and their derivatives in Saccharomyces cerevisiae: bioconversion from glucose. FEMS Yeast Research 17 (4), 1. Juni 2017; fox035.
  doi:10.1093/femsyr/fox035
• W.C. Generoso, V. Schadeweg, M. Oreb, E. Boles: Metabolic engineering of Saccharomyces cerevisiae for production of butanol isomers. Current Opinion on Biotechnology 33, 2017; S. 1–7.
  doi:10.1016/j.copbio.2014.09.004
  .
• Leonie Baumann, Arun S. Rajkumar,
  doi:10.1021/acssynbio.8b00309
  .

External links

• Homepage Prof. Dr. Eckhard Boles at Goethe University Frankfurt