Efungumab
IV only) | |
|---|---|
| Protein binding | High |
| Elimination half-life | 1–2 hours |
| Identifiers | |
| CAS Number | |
| ChemSpider |
|
| UNII | |
| KEGG | |
| Chemical and physical data | |
| Molar mass | Approximately 27.2 kg/mol |
  (what is this?) (verify) | |
Efungumab (trade name Mycograb) was a
candidemia (a bloodstream infection caused by pathogenic yeast) in combination with amphotericin B. The European Medicines Agency has twice refused to grant marketing authorization for Mycograb, citing product safety and quality issues.[1]
Chemically, efungumab is a single-chain variable fragment of a human monoclonal antibody.[2] As such, it "grabs" onto fungal hsp90, hence its proposed trade name.
Its ability to potentiate the effects of the antifungal amphotericin B in culture were later found to be non-specific.[3]
References
- KiB). London: European Medicines Agency. Retrieved on 2007-11-20. Detailed assessment report with comprehensive overview of reasons for refusal of marketing authorization.
- ^ World Health Organization (2006). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 95" (PDF). WHO Drug Information. 20 (2): 48. Archived from the original (PDF) on September 19, 2007.
- PMID 22508314.
 | This monoclonal antibody–related article is a stub. You can help Wikipedia by expanding it. |