Eicosatetraenoic acid

Source: Wikipedia, the free encyclopedia.

Eicosatetraenoic acid (ETA) designates any straight chain 20:4

cell-cell communication. The eicosanoids, working in tandem, contribute to a lipid signaling complex widely responsible for inducing an inflammatory immune response.[1] Common signs of inflammation are both internal and external, with effects like visible redness, pain in the surrounding area, swelling, and the sensation of heat—many of these an effect of varying eicosanoid species.[2] These effects are associated with and have been observed in patients with cancers and various neurological/metabolic disorders.[3]

See Essential Fatty Acid for nomenclature.

Two isomers, both of them essential fatty acids, are of particular interest:

Some chemistry sources define 'arachadonic acid' to designate any of the eicosatetraenoic acids. However, almost all writings in biology, medicine and nutrition limit the use of the term 'arachidonic acid' to all-cis-5,8,11,14-eicosatetraenoic acid (ω-6).

Related studies

ETA is found in

green-lipped mussel and appears to act as dual inhibitor of arachidonic acid oxygenation by both the cyclooxygenase (COX) and lipoxygenase pathway.[4]

Mutant of

Mortierella alpina 1S-4 is a fungus employed for producing arachidonic acid. These mutants produce larger amounts of ETA due to the expression of an ω-3-desaturase gene, typically responsible for the significant production of the more abundant PUFAs.[5]

In addition to their inflammatory nature, eicosanoids such as ETA can also contribute to an anti-inflammatory response.[5]

See also

References

  1. PMID 26139350
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  2. PMID 23760108
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  3. PMID 32322464.[permanent dead link
    ]
  4. PMID 12042477
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  5. ^
    PMID 25845716
    .
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