Enteroglucagon

Source: Wikipedia, the free encyclopedia.

Enteroglucagon is a

colon and terminal ileum.[1]
It consists of 37 amino acids. Enteroglucagon is released when fats and glucose are present in the small intestine; which decrease the motility to allow sufficient time for these nutrients to be absorbed.

Discovery

In 1948, Sutherland and De Duve identified a gastrointestinal glucagon-like material in gastric mucosa,[2] the term "enteroglucagon" was used to describe this material that shared a similar immunoreactivity with glucagon.[3] A half-century later, Brubaker and Drucker[4] studied proglucagon gene expression, they discovered the function of enteroglucagon is related to the growth of intestinal epithelium.[5]

Function

Enteroglucagon is a proglucagon-derived peptide or enteroendocrine cells derived peptide in the small intestine. Preproglucagon undergoes

negative feedback loop between glucose and insulin level, it promotes insulin release from beta cells of pancreas islet and suppresses glucagon when the glucose level is high.[7] In vertebrate mammals, GLP-2 sequences are highly conversed in the intestine.[2] The molecule functions as a part of adaptive response, such that contributes intestinal growth, proliferation effect, intestinal dilation (increases the mucosal blood flow) and reduces the chance of apoptosis.[2]

Clinical significance

GLP-1 is effective at reducing blood glucose levels. GLP-1 analogs have a significant therapeutic effect and high efficacy on diabetes treatments and hypoglycemia prevention.[8] Proliferation effect and trophic effect on the small intestine, GLP-2 is used as a therapy to support patients with short-bowel syndrome and other underlying intestinal conditions.[9]

See also

References

  1. PMID 9074764
    .
  2. ^
    S2CID 8182049
    .
  3. PMID 31971745
    , retrieved 2021-05-02
  4. S2CID 35172107
    .
  5. PMID 8755576
    .
  6. S2CID 12334916
    .
  7. PMID 31971745
    , retrieved 2021-04-30
  8. PMID 25678953
    .
  9. PMID 14608103
    .

External links
Retrieved from "https://en.wikipedia.org/w/index.php?title=Enteroglucagon&oldid=1215622089"