Eric John Holborow

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Eric John Holborow
Born(1918-03-20)20 March 1918
Amesbury, Wiltshire
Died3 February 2009(2009-02-03) (aged 90)
Ashford, Kent[1]
NationalityBritish
Occupation(s)Physician and immunologist
Known forfirst description of autoantibodies to smooth muscle[2][3]

Eric John Holborow

FRCP (1918–2009) was a British physician, rheumatologist, and immunologist, known for his pioneering research on autoimmunity.[4][5]

After education at Epsom College, Eric John Holborow, known as "John" or "EJ", studied medicine at Clare College, Cambridge and St Bartholomew's Hospital, graduating in 1942 MB BChir (Cantab.). In 1942 immediately after qualifying MRCS, LRCP, he joined the RAMC and served (under the command of John Vivian Dacie from 1943 to 1946) in Egypt. Holborow in 1947 joined the Royal Postgraduate Medical School's department of haematology (where Dacie was a senior lecturer) and in 1953 graduated MD.[4]

In 1953 Holborow joined the scientific staff of the MRC Rheumatism Research Unit at the Canadian Red Cross Memorial Hospital in Taplow, Buckinghamshire. He eventually became the director of the Rheumatism Research Unit and worked there until the Unit was closed in 1976.[4]

While he was there he was particularly involved in perfecting the new technique of using immunoflourescence to define autoantibodies in many diseases, providing much of the basis for modern diagnostics. With his colleagues, he was the first to describe smooth muscle reactive autoantibodies and this led the way to important immunological discoveries in the fields of liver disease, viral infections and neoplasia. While there he made a point of developing activities for the children hospitalised through arthritis.[4]

With Leonard Glynn, he was one of the first scientists to explore the contribution of autoimmunity to rheumatic fever, inflammatory arthritis and systemic CTDs in patients and animal models of autoimmune disease, and with his clinical collaborators, Eric Bywaters and Barbara Ansell, he created a model centre for the scientific basis of investigating patients with rheumatic diseases.[5]

He was in 1956 a founder member of the British Society for Immunology and in 1959 became the Society's second secretary.[5]

Together with Leonard Glynn ... he published Autoimmunity and disease (Oxford, Blackwell, 1965) which was regarded as a landmark text in the field and has been described as ‘a model of scientific writing’. He also wrote An ABC of modern immunology (London, Lancet Ltd, 1968).[4]

In 1976 the Arthritis and Rheumatism Campaign set up the Bone and Joint Research Unit at the London Hospital Medical College (LHMC) in Whitechapel. Holborow was appointed the head of the Bone and Joint Research Unit[4] and was given a professorial chair in immunopathology.[5] He was a co-editor for The Journal of Immunological Methods[5] and a co-editor with William Gordon Reeves of two editions of Immunology in Medicine: A Comprehensive Guide to Clinical Immunology (London, Academic Press, 1977, 1983). Holborow was elected FRCP in 1978 and was the Bradshaw Lecturer in 1982. He retired in 1983.[4]

He married in 1943. Upon his death in 2009 he was survived by his widow, two sons, a daughter, six grandchildren, and two great-grandchildren.[4]

Selected publications

References

  1. ^ "Lasting Tribute page for Eric John Holborow". funeral-notices.co.uk.
  2. ^ Johnson GD; Holborow EJ; Glynn LE (30 October 1965). "Antibody to smooth muscle in patients with liver disease". 286 (7418): 818–819. {{cite journal}}: Cite journal requires |journal= (help)
  3. PMID 93995
    .
  4. ^ a b c d e f g h "Eric John Holborow". Munk's Roll, Volume XII, Royal College of Physicians.
  5. ^
    doi:10.1093/rheumatology/kep318
    .
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