Fananserin

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Fananserin
Clinical data
Other namesFananserin
ATC code
  • none
Identifiers
  • 2-(3-(4-(p-Fluorophenyl)-1-piperazinyl)propyl)-2H-naphth(1,8-cd)isothiazole 1,1-dioxide
JSmol)
  • C1CN(CCN1CCCN2C3=CC=CC4=C3C(=CC=C4)S2(=O)=O)C5=CC=C(C=C5)F
  • InChI=1S/C23H24FN3O2S/c24-19-8-10-20(11-9-19)26-16-14-25(15-17-26)12-3-13-27-21-6-1-4-18-5-2-7-22(23(18)21)30(27,28)29/h1-2,4-11H,3,12-17H2 ☒N
  • Key:VGIGHGMPMUCLIQ-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Fananserin (RP-62203) is a drug which acts as a potent

antagonist at both the 5HT2A receptor,[1] and the Dopamine D4 receptor,[2] but without blocking other dopamine receptors such as D2.[3] It has sedative[4] and antipsychotic effects, and has been researched for the treatment of schizophrenia,[5] although efficacy was less than expected and results were disappointing.[6]

References

  1. PMID 1908521
    .
  2. PMID 8957240
    .
  3. PMID 1596688
    .
  4. PMID 1579785
    .
  5. PMID 10513457
    .
  6. S2CID 41422352
    .
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