The global war on terror emphasizes the need for a weapon system that can improve the self-defense capability of the U.S Navy ship against small surface craft threats. This MSSE Capstone Project investigated the feasibility of integrating the Non-Line of Sight Launching System (NLOS-LS) onto U.S. Navy ships. In particular, the focus of the project was on the DDG-51 class ships. The NLOS-LS was originally designed to provide support to Army ground forces against over the horizon threats. The U.S. Navy recognizes the prospect of this weapon in an at-sea environment. The capability of the system has been proven through its developmental testing to date and illustrates the potential to the U.S. Navy for ship defense. System integration involves incorporating a stand-alone, land-based system onto a ship with an existing shipboard combat system. This report addresses the top-level integration issues, such as the physical installation and combat system integration, and provides recommendations related to some important concerns that include interface analysis, functional analysis, system behavior, and physical installation. This analysis concludes with a notional implementation for many issues and provides a risk analysis for those issues. It also identifies many integration areas requiring further research.