George Heist

George D. Heist (1886–1920) was an

meningococcal bacteria that often result in meningococcal disease

, which is well known as highly lethal and debilitating, and extremely difficult to treat.

In 1919, Dr Heist and co-workers [Heist et al., 1922]

capillary tube. When Heist, whose blood had no bactericidal activity, acquired an N. meningitidis infection, the link between serum bactericidal activity and resistance to meningococcal infection was proven" (Pollard et al. 2004, p. 1812).^[2]

"Dr. George D. Heist of Philadelphia, a
lupus. They excluded properdin deficiency, which can be accompanied by susceptibility to meningococcal meningitis, because of its X-linked inheritance (312060)." (McKusic, 2005)^[4]

Notes

^ Heist GD, Solis-Cohen S, Solis-Cohen M. (1922). A study of the virulence of meningococci for man and of human susceptibility to meningococcic infection. J Immunol;7:1–33.
^ Pollard AJ, Ochnio J, Ho M, Callaghan M, Bigham M, Dobson S. (2004). Disease Susceptibility to ST11 Complex Meningococci Bearing Serogroup C or W135 Polysaccharide Capsules. Emerging Infectious Diseases;10:1812-1815.
^ Schifferli, J. A.; Hirschel, B. (1985). Meningococcal meningitis in the first case of complement deficiency. (Letter) Lancet II: 1240.
^ McKusic, VA. (2005). Complement Component 5 Deficiency. Online Mendelian Inheritance in Man; #609536.

References

Goldschneider I, Gotschlich EC, Artenstein MS. (1969). "Human immunity to the meningococcus, I: the role of humoral antibodies." J Exp Med;129:1307-1326

[1] Heist GD, Solis-Cohen S, Solis-Cohen M. (1922). A study of the virulence of meningococci for man and of human susceptibility to meningococcic infection. J Immunol;7:1–33.

[2] Pollard AJ, Ochnio J, Ho M, Callaghan M, Bigham M, Dobson S. (2004). Disease Susceptibility to ST11 Complex Meningococci Bearing Serogroup C or W135 Polysaccharide Capsules. Emerging Infectious Diseases;10:1812-1815.

[3] Schifferli, J. A.; Hirschel, B. (1985). Meningococcal meningitis in the first case of complement deficiency. (Letter) Lancet II: 1240.

[4] McKusic, VA. (2005). Complement Component 5 Deficiency. Online Mendelian Inheritance in Man; #609536.

[2]