George Wallace Kenner

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George Wallace Kenner

organic chemist.[1] He was born in Sheffield in 1922, the son of Prof. James Kenner. During his childhood, he went to Didsbury Preparatory School in 1928 and moved to Manchester Grammar School in 1934. He was appointed to the first Heath Harrison Chair of Organic Chemistry at the University of Liverpool
1957–1976. He did his MSc and PhD degrees under Lord Todd at Manchester and Cambridge Universities in UK. He married Jillian Bird in 1951 and they had two daughters both born in Cambridge. He was faculty member at the Cambridge University for 15 years before moving to the University of Liverpool in 1957 as Heath Harrison Professor of Organic Chemistry.

Achievements

George Kenner contributed to many areas of organic chemistry. In the 1960s, George Kenner, R.A. Gregory and Hilda Tracy were involved in the seminal discovery and synthesis of the peptide hormone gastrin at the University of Liverpool.[2][3] Gastrin is involved in secretion of gastric acid (HCl) in the stomach.

The first chemical synthesis of a lysozyme-like enzyme of 129 amino acids using the classical approach was attempted by Kenner and his group at the University of Liverpool in 1970s. This would have been the largest protein molecules synthesised in a laboratory using classical peptide synthesis up to that time.[4] He carefully planned a convergent synthesis of this lysozyme analogue, containing 129 amino acid residues joined in a rigorously defined order. The efforts of Kenner and his group led to the synthesis of the 129 amino acid peptide chain in protected form. But the dream of making a wholly synthetic lysozyme enzyme was only achieved in 2007. The synthesis of functionally active lysozyme was done 30 years later by a single individual, Thomas Durek, working in Steve B. Kent's group at the University of Chicago.[5] The value of George Kenner's contributions to the methodology of peptide chemistry had profoundly influence on the developments in many biomedicine fields. For example it led to the synthesis of antigens of defined geometry for immunological studies.[6][7]

Kenner's work has been recognised by the awards of the

Bakerian Lecturer
for 1976 and was elected to a Royal Society Research Professorship in 1976.

The Kenner Prize and Awards at University of Liverpool

George Kenner Prize and Lectureship was established in 1979 with a sum of £12,000 raised by subscription to commemorate the late Professor GW Kenner, Heath Harrison Professor of Organic Chemistry from 1957 to 1976 and Royal Society Professor from 1977 to 1978. The duty of the Lectureship recipient is to deliver lectures on subjects related to the study of Organic Chemistry at the University. Several famous organic chemists were awarded this honour and these include

Ryoji Noyori, Steven V. Ley, Albert Eschenmoser, John George Adami, Duilio Arigoni, and Jean-Marie Lehn
. The George W. Kenner Award for graduate students was established in 2006 to commemorate Kenner who spent almost 21 years in the Chemistry department at the University of Liverpool as the Heath Harrison Professor of Organic Chemistry. The award is annually given to the first-year PhD student in the organic section of the Department of Chemistry who is the best in both academic and research performance.

References

  1. ^ Lord A. R. Todd (1979). George Wallace Kenner. 16 November 1922 – 26 June 1978. Source: Biographical Memoirs of Fellows of the Royal Society, Vol. 25, pp. 390–420. URL https://www.jstor.org/stable/769853
  2. PMID 14159395
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  3. S2CID 4262131
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  4. S2CID 170906912
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  5. PMID 17360367
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  6. PMID 591685
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  7. S2CID 41512330
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