Glomerulus (cerebellum)

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dendrites and pre-synaptic terminals of mossy fibers.[1]

Function

The cerebellar glomeruli are the first "processing station" for

inhibitory signals, while information is passed on to the granule and Golgi cells from the mossy fiber.[2]

Structure

A cerebellar glomerulus is about 2.5 um in diameter, and is wrapped by glial sheathing. Glomeruli are centered on the large axonal terminals of glutamatergic afferent mossy fibers. Each terminal comes into contact with dendrites from 50 to 60 different granule cells. The granule cells themselves each have a single or multiple dendrites, and each participates in a different glomerulus. Glomeruli also contain the GABAergic (inhibitory) synapses of Golgi cells onto granule cells, and the glutamatergic (excitatory) synapses from mossy fibers onto Golgi cells.[3] Each glomerulus contains approximately 50 granule cell dendrites, 210 total dendritic digits and 230 synaptic junctions.[4]

Velate astrocytes

Velate astrocytes are glia that sheath the glomeruli. They are

extracellular calcium to regulate signaling.[7]

References

  1. ^ "Cerebellar glomerulus". NeuroLex. The Neuroscience Information Framework. 14 Oct 2011. Retrieved 24 June 2014.
  2. ISBN 978-1-4511-1045-6
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  3. S2CID 12730864
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  4. PMID 8959547
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  5. ^ "Velate astrocyte". NeuroLex. The Neuroscience Information Framework. 29 May 2009. Retrieved 24 June 2014.
  6. S2CID 6647091
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  7. ^ Olivier, D. E. et al. (2001) Cerebellar glomeruli: Does limited extracellular calcium implement a sparse encoding strategy? Proceedings of the 8th Annual Joint Symposium on Neural Computation
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