Haldane's sieve
notability.(October 2023) ) |
Haldane's sieve is a concept in population genetics named after the British geneticist J. B. S. Haldane. It refers to the fact that dominant advantageous alleles are more likely to fix in the population than recessive alleles.[1] Haldane's sieve is particularly relevant in situations where the effects of natural selection are strong and the beneficial mutations have a significant impact on an organism's fitness.
According to Haldane's sieve, when a new advantageous mutation arises in a population, it initially occurs as a single copy (a
When adaptation stems from the species pool of standing genetic variation, a "soft sweep", the rationale does not apply, because the allele is no longer rare in the beginning of the sweep. In fact, recessive alleles are more likely to sweep than dominant sweeps when alleles are previously maintained in the population.[2]
Haldane's sieve has important implications for understanding the dynamics of adaptation and evolution in
See also
- Population genetics
- Selective sweep
- Natural selection
- Adaptive evolution