Hugh Pelham
Sir Hugh Pelham | |
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Born | Hugh Reginald Brentnall Pelham 26 August 1954[3] |
Education | Marlborough College |
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Spouse | [3][5] |
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Scientific career | |
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Thesis | Transcription and Translation in Reticulocyte Lysates (1978) |
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Website | www2 |
Sir Hugh Reginald Brentnall Pelham,
Education
Pelham was educated at
Career and research
Pelham is an authority on the movement of proteins within cells. Pelhams's work has explained how some proteins can protect cells from damage. He has also shown how cells remove damaged or unwanted proteins – vital for maintaining their healthy functioning. More recently, his research investigates how proteins are modified and sorted to their correct places within cells and aims to find ways of blocking these processes.[7][10][11][12][13]
Pelham has been a visiting professor at the
Awards and honours
Pelham was
Distinguished for his contributions to protein biosynthesis, the control of gene activity and intracellular sorting. He developed a sensitive in vitro translation system, with which he discovered that naturally "leaky" termination codons exist in plant virus RNAs, and achieved the first correct synthesis and processing of viral polyproteins in vitro. He showed that the transcription factor TFIIIA, which is required in Xenopus oocytes for 5S rDNA transcription, binds to the gene product, %S RNA and is present in large amounts in oocytes. From studies on heat shock genes, he identified the first regulatory DNA sequence (the "Pelham" box) in a eukaryotic gene, proving this alone could confer heat inducibility on another gene. He has shown that this sequence is the binding site for a transcription factor which is modified by heat shock, thus establishing the basic mechanism of induction of these genes. He has clarified the function of heat shock proteins, finding that two of these reside in the lumen of the endoplasmic reticulum. This led to his discovery that a C-terminal amino acid sequence is a novel sorting signal, preventing proteins from being exported from the lumen of the endoplasmic reticulum.[14]
Pelham gave the
References
- ^ a b "Professor Hugh R. Pelham Winner of the 1996 KFIP Prize for Science". Archived from the original on 10 December 2015.
- ^ Louis-Jeantet Prize
- ^ a b c d e Anon (2015). "Pelham, Sir Hugh (Reginald Brentnall)". Who's Who (online Oxford University Press ed.). A & C Black. (Subscription or UK public library membership required.)
- PMID 21220504.
- ^ "BIENZ, Dr Mariann, (Lady Pelham)". Who's Who. Vol. 2015 (online Oxford University Press ed.). A & C Black. (Subscription or UK public library membership required.)
- ^ Academy of Medical Sciences. Archived from the originalon 10 December 2015.
- ^ a b c d e f "Sir Hugh Pelham FMedSci FRS". London: Royal Society. Archived from the original on 17 November 2015.
- ^ PMID 23741620.
- EThOS uk.bl.ethos.468626. Archived from the originalon 18 September 2018. Retrieved 18 September 2018.
- ^ Hugh Pelham's publications indexed by the Scopus bibliographic database. (subscription required)
- PMID 823012.
- S2CID 40952713.
- S2CID 24942115.
- ^ "Certificate of election EC/1988/30: Pelham, Hugh Reginald Brentnall". London: Royal Society. Archived from the original on 12 December 2021. Retrieved 10 December 2015.
- ^ "EMBO member: Hugh R.B. Pelham". Heidelberg: EMBO.