Human maximisation test
The Human maximisation test (HMT) is a test method for testing for contact allergens. It was first developed by Albert Kligman in 1966[1] and updated by Kligman and William Epstein in 1975.[2] The first paper appeared 1966[3] and was a citation classic in 1985.[4]
The test uses human medical volunteers (usually 25) and
sodium laureth sulphate to maximise. Because of the potentially large human reaction, it is generally not considered ethical to use today.[5] It does not have a guideline under the OECD Guidelines for the Testing of Chemicals. It has been compared with the murine local lymph node assay[6][7]
See also
References
- ^ The Identification of Contact Allergens by Human Assay III. The Maximization Test: A Procedure for Screening and Rating Contact Sensitizers http://www.nature.com/jid/journal/v47/n5/abs/jid1966160a.html
- S2CID 35702783.
- PMID 5924294.
- ^ http://garfield.library.upenn.edu/classics1985/A1985AUG6800001.pdf [bare URL PDF]
- ^ "Opinion concerning the predictive testing of potentially cutaneous sensiting cosmetic ingredients or mixtures of ingredients adopted by the SCCNFP during the 11th plenary session of 17 February 2000 | Scientific Committees".
- ^ DA Basketter, EW Scholes, I Kimber (1994). The performance of the local lymph node assay with chemicals identified as contact allergens in the human maximization test. Food and Chemical Toxicology, 1994 - Elsevier
- S2CID 35683477.