IRS2
(Redirected from
Insulin receptor substrate 2
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| Location (UCSC) | Chr 13: 109.75 – 109.79 Mb | Chr 8: 11.03 – 11.06 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Insulin receptor substrate 2 is a protein that in humans is encoded by the IRS2 gene.[5]
Function
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of
IL4 treatment.[6]
Mice lacking IRS2 have a diabetic phenotype[7] as well as a 40% reduction in brain mass.[8]
Interactions
IRS2 has been shown to
interact
with:
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000185950 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038894 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 9312143.
- ^ "Entrez Gene: IRS2 insulin receptor substrate 2".
- PMID 15467829.
- PMID 12904469.
- PMID 9535722.
- PMID 12228220.
- PMID 8910607.
- PMID 9334184.
- PMID 9852124.
- PMID 12107746.
Further reading
- White MF (1999). "The IRS-signalling system: a network of docking proteins that mediate insulin action". Mol. Cell. Biochem. 182 (1–2): 3–11. S2CID 32623861.
- Jiang H, Harris MB, Rothman P (2000). "IL-4/IL-13 signaling beyond JAK/STAT". J. Allergy Clin. Immunol. 105 (6 Pt 1): 1063–70. PMID 10856136.
- Sesti G, Federici M, Hribal ML, et al. (2001). "Defects of the insulin receptor substrate (IRS) system in human metabolic disorders". FASEB J. 15 (12): 2099–111. S2CID 6429338.
- Gibson SL, Ma Z, Shaw LM (2007). "Divergent roles for IRS-1 and IRS-2 in breast cancer metastasis". Cell Cycle. 6 (6): 631–7. PMID 17361103.
- Dearth RK, Cui X, Kim HJ, et al. (2007). "Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2". Cell Cycle. 6 (6): 705–13. PMID 17374994.
- Johnston JA, Wang LM, Hanson EP, et al. (1996). "Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases". J. Biol. Chem. 270 (48): 28527–30. PMID 7499365.
- Patti ME, Sun XJ, Bruening JC, et al. (1995). "4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice". J. Biol. Chem. 270 (42): 24670–3. PMID 7559579.
- Sun XJ, Wang LM, Zhang Y, et al. (1995). "Role of IRS-2 in insulin and cytokine signalling". Nature. 377 (6545): 173–7. S2CID 4336107.
- Ridderstråle M, Degerman E, Tornqvist H (1995). "Growth hormone stimulates the tyrosine phosphorylation of the insulin receptor substrate-1 and its association with phosphatidylinositol 3-kinase in primary adipocytes". J. Biol. Chem. 270 (8): 3471–4. PMID 7876077.
- Platanias LC, Uddin S, Yetter A, et al. (1996). "The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2". J. Biol. Chem. 271 (1): 278–82. PMID 8550573.
- Beitner-Johnson D, Blakesley VA, Shen-Orr Z, et al. (1996). "The proto-oncogene product c-Crk associates with insulin receptor substrate-1 and 4PS. Modulation by insulin growth factor-I (IGF) and enhanced IGF-I signaling". J. Biol. Chem. 271 (16): 9287–90. PMID 8621590.
- Sawka-Verhelle D, Tartare-Deckert S, White MF, Van Obberghen E (1996). "Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786". J. Biol. Chem. 271 (11): 5980–3. PMID 8626379.
- He W, Craparo A, Zhu Y, et al. (1996). "Interaction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. Evidence for two distinct phosphotyrosine-dependent interaction domains within IRS-2". J. Biol. Chem. 271 (20): 11641–5. PMID 8662806.
- Zhang WR, Li PM, Oswald MA, Goldstein BJ (1996). "Modulation of insulin signal transduction by eutopic overexpression of the receptor-type protein-tyrosine phosphatase LAR". Mol. Endocrinol. 10 (5): 575–84. S2CID 42128485.
- Argetsinger LS, Norstedt G, Billestrup N, et al. (1997). "Growth hormone, interferon-gamma, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling". J. Biol. Chem. 271 (46): 29415–21. PMID 8910607.
- Thiselton DL, Hampson RM, Nayudu M, et al. (1997). "Mapping the RP2 locus for X-linked retinitis pigmentosa on proximal Xp: a genetically defined 5-cM critical region and exclusion of candidate genes by physical mapping". Genome Res. 6 (11): 1093–102. PMID 8938433.
- Izuhara K, Harada N (1997). "Interleukin-4 activates two distinct pathways of phosphatidylinositol-3 kinase in the same cells". Biochem. Biophys. Res. Commun. 229 (2): 624–9. PMID 8954948.
- Vanhaesebroeck B, PMID 9113989.
- Sawka-Verhelle D, Baron V, Mothe I, et al. (1997). "Tyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptor". J. Biol. Chem. 272 (26): 16414–20. PMID 9195949.
- Algenstaedt P, Antonetti DA, Yaffe MB, Kahn CR (1997). "Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart". J. Biol. Chem. 272 (38): 23696–702. PMID 9295312.