Integra LifeSciences

Integra LifeSciences is a global medical device manufacturing company headquartered in Princeton, New Jersey.^[3][4] Founded in 1989, the company manufactures products for skin regeneration, neurosurgery, reconstructive and general surgery.^[3] Integra artificial skin became the first commercially reproducible skin tissue used to treat severe burns and other skin wounds.^[5][6]

History

Integra LifeSciences was founded by

In 1996, Integra artificial skin was approved by the U.S. Food and Drug Administration.[8] The artificial skin, manufactured and patented as Integra, is now used on patients with extensive burns.^[5] In 1999, the FDA approved Integra LifeSciences’ DuraGen, an absorbable implant used in neurosurgical and spinal procedures.^[9]

In 2001, NMT, a company acquired by Integra in 2002 ^[10], received FDA approval for Licox, a brain tissue oxygen and temperature monitor.^[11][12] Licox is used to treat patients in critical care, including those suffering from traumatic brain injuries.^[11]

In 2002, the FDA approved the use of Integra Dermal Regeneration Template for reconstructive surgery of burn scars.^[13] In 2016, IDRT received premarket approval from the FDA for the treatment of diabetic foot ulcers.^[14]

In 2018, Integra LifeSciences was included in Fortune’s list of Fastest Growing Companies.^[15]

In 2023, Integra ranked #59 on Medical Design and Outsourcing’s list of largest medical technology companies in the world.^[16]

Integra artificial skin

In 1969,

Integra is used to treat patients with severe burns.[5]^[6][8] The top layer, made of thin silicone, protects the patient from infection and dehydration, common causes of death after being severely burned.^[5][8] The bottom layer, made of animal tissue, acts as scaffolding where new skin will grow.^[5][17] Compared to traditional skin grafts, the use of Integra reduces pain and scarring.^{[5][8][17][6]}

Integra is also used in plastic surgery, reconstructive surgery, and to treat some forms of cancer and other skin wounds.^{[6][18][19][20]}

Acquisitions

In October 2014, Integra LifeSciences acquired instrumentation lines from Medtronic for $60 million.^[21] In January 2014, the company bought Covidien’s Confluent Surgical line of sealants and shields.^[22]

In July 2015, Integra LifeSciences acquired TEI Biosciences and TEI Medical and began manufacturing their SurgiMend and PriMatrix product lines.^[23][24] Primatrix, a dermal repair scaffolding product, is used to treat diabetic foot ulcers, burns, and in other procedures.^[25][26]

In January 2017, Integra Lifesciences acquired Derma Sciences for $204 million.^[27] Their TCC-EZ Total Contact Cast, used to treat diabetic foot ulcers, reduces pressure and shortens application time compared to a conventional total contact cast.^[27][28][29]

In October 2017, Integra LifeSciences acquired Johnson & Johnson’s Codman Neurosurgery business for $1.045 billion.^[30] The Codman Hakim valve was developed as a new way to treat hydrocephalus.^[31][32]

In January 2021, the company acquired regenerative medicine firm, ACell, for $400M.^[33][34]

References