Intussusceptive angiogenesis

Source: Wikipedia, the free encyclopedia.
For other uses, see Intussusception (disambiguation).

Intussusceptive angiogenesis also known as splitting angiogenesis, is a type of angiogenesis, the process whereby a new blood vessel is created. By intussusception a new blood vessel is created by splitting of an existing blood vessel in two.[1][2][3] Intussusception occurs in normal development as well as in pathologic conditions involving wound healing,[4] tissue regeneration, inflammation as colitis[5][6] or myocarditis,[7] lung fibrosis,[8] and tumors[9][10] amongst others.

Intussusception was first observed in neonatal rats. In this type of vessel formation, the

endothelial cells. This is especially important in embryonic development as there are not enough resources to create a rich microvasculature with new cells every time a new vessel develops.[citation needed
]

A process called coalescent angiogenesis[11][12] is considered the opposite of intussusceptive angiogenesis. During coalescent angiogenesis capillaries fuse and form larger vessels to increase blood flow and circulation. Several other modes of angiogenesis have been described, such as sprouting angiogenesis, vessel co-option and vessel elongation.[13]

Research

In a small study comparing the lungs of patients who had died from

influenza A pneumonia (H1N1) to uninfected controls during autopsy; there was a significantly greater density of intussusceptive angiogenic features in the lungs of patients who had died from Covid-19 as compared to influenza A and the control group. The degree of intussusceptive angiogenic features in the lungs from the Covid-19 patients were also found to be greater as the length of hospitalization increased (which was not seen in the influenza or control groups). This suggests that increased or enhanced intussusceptive angiogenesis is seen in Covid-19 and may play a role in pathogenesis.[14][15]

References

  1. S2CID 45113283
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  2. S2CID 8145437
    .
  3. PMID 22739226
    .
  4. PMID 21217515
    .
  5. PMID 20225210
    .
  6. PMID 23485588
    .
  7. PMID 32101607
    .
  8. S2CID 208742259
    .
  9. PMID 22197620
    .
  10. S2CID 55783
    .
  11. PMID 34905124
    .
  12. S2CID 254188870
    .
  13. PMID 37060495
    .
  14. PMID 32437596
    .
  15. ^ "Injury patterns in COVID-19 lungs". Panta Rhei Study Group. Retrieved 6 July 2020.
  • Mentzer SJ, Konerding MA. Intussusceptive angiogenesis: Expansion and remodeling of microvascular networks. Angiogenesis 2014;17:499-509.
  • Vascular remodeling by intussusceptive angiogenesis, Djonov V, Baum O, Burri PH., Cell and Tissue Research, 2003 Oct;314(1):107-17
  • Ackermann M, Verleden SE, Kuehnel M, et al. Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 [published online ahead of print, 2020 May 21]. N Engl J Med. 2020;10.1056/NEJMoa2015432. doi:10.1056/NEJMoa2015432
  • www.intussusception.org
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