Inverted microscope
An inverted microscope is a
Construction
The stage of an inverted microscope is usually fixed, and focus is adjusted by moving the
Depending on the size of the microscope, four to six objective lenses of different magnifications may be fitted to a rotating turret known as a nosepiece. These microscopes may also be fitted with accessories for fitting still and video cameras,
Biological applications
Inverted microscopes are useful for observing living cells or organisms at the bottom of a large container (e.g., a tissue culture flask) under more natural conditions than on a glass slide, as is the case with a conventional microscope. An inverted microscope is also used for visualisation of the mycobacterium tuberculosis bacteria in the technique called Microscopic Observation Drug Susceptibility assay (MODS).
Micromanipulation
Inverted microscopes are used in micromanipulation applications where space above the specimen is required for manipulator mechanisms and the microtools they hold, and in metallurgical applications where polished samples can be placed on top of the stage and viewed from underneath using reflecting objectives.
References
- ^ Smith JL (1852). "The inverted microscope-a new form of microscope". Am J Sci Arts. 14: 233–241.
External links
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