JWH-015

Source: Wikipedia, the free encyclopedia.
JWH-015
Legal status
Legal status
Identifiers
  • (2-Methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone
JSmol)
  • CCCN1C(=C(C2=CC=CC=C21)C(=O)C3=CC=CC4=CC=CC=C43)C
  • InChI=1S/C23H21NO/c1-3-15-24-16(2)22(20-12-6-7-14-21(20)24)23(25)19-13-8-10-17-9-4-5-11-18(17)19/h4-14H,3,15H2,1-2H3 ☒N
  • Key:LJSBBBWQTLXQEN-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

JWH-015 is a chemical from the

immunomodulatory effects,[4][5] and CB2 agonists may be useful in the treatment of pain and inflammation.[6][7] It was discovered and named after John W. Huffman
.

Metabolism

JWH-015 has been shown in vitro to be metabolized primarily by

carcinogenic metabolites, although there is no evidence to show that JWH-015 or other aminoalkylindole cannabinoids are actually carcinogenic in vivo. JWH-015 may signal certain cancers to shrink through a process called apoptosis.[10]

Legal status

In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-015 are

Schedule I Controlled Substances.[11]

As of October 2015 JWH-015 is a controlled substance in China.[12]

References

  1. PMID 10940540
    .
  2. PMID 22921769
    .
  3. PMID 18289088
    .
  4. PMID 16503355
    .
  5. S2CID 5896815
    .
  6. PMID 1352348
    .
  7. PMID 17413917
    .
  8. S2CID 9116612
    .
  9. S2CID 10848076
    .
  10. PMID 19690545
    .
  11. ^ 21 U.S.C. § 812: Schedules of controlled substances
  12. ^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" [Notice on Issuing the Measures for the Listing and Control of Non-Medicinal Narcotic Drugs and Psychotropic Substances] (in Chinese). China Food and Drug Administration. 27 September 2015. Archived from the original on 1 October 2015. Retrieved 1 October 2015.
Retrieved from "https://en.wikipedia.org/w/index.php?title=JWH-015&oldid=1186931275"