JacSue Kehoe

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JacSue Kehoe
Born(1935-10-23)October 23, 1935
CRNS
AwardsForbes Lectureship, 1977

JacSue Kehoe (October 23, 1935 – June 25, 2019) was an American neuroscientist and

Centre national de la recherche scientifique,[2]
where she made many other discoveries in neuroscience.

Early life

JacSue Kehoe was born on October 23, 1935, in Cleveland, Ohio.[2] Her mother was a former doctoral candidate turned English teacher. Her father was an employee of the Chrysler Corporation. The youngest of three, Kehoe and her family moved to Evansville, Indiana, for the duration of World War II for her father’s work.[2] After the war they migrated back to the city, where Kehoe discovered her interest in the performing arts. She became assistant to the dramatic arts teacher at her high school: this position inspired her to become a theater director.[2] She attended Northwestern University to pursue a degree in theater.[2]

After two years pursuing her theater degree,[2] she switched her major to experimental psychology. Human behavior was a major interest of the field. Kehoe performed experiments testing memory for her honor’s thesis. After two years she graduated Northwestern with a bachelor's degree in experimental psychology.[2]

Kehoe continued her education at Brown University.[2] She focused on the function of the nervous system and its relation to psychology, furthering her understanding of human memory.[2] She performed experiments concerning the proactive and retroactive inhibition of memory retention on pigeons,[4] earning her Ph.D. in 1961.

Career

Kehoe joined the psychology faculty of

Aplysia californica, a species of sea slug, to study circadian rhythms. These cells were ideal for studying the effects of neurotransmitters on neuron behavior: using discarded Aplysia ganglia and equipment provided by Strumwasser’s lab, Kehoe began her study of synaptic physiology.[2]

In 1964 Kehoe moved to Paris to continue her work on Aplysia

Cholinergic antagonist, to this end, she observed instead a change in the cells' spontaneous synaptic activity.[2] This activity was unusual, so she refocused her research on this hyperpolarizing response for several years. After many tests using a setup of her own design Kehoe discovered that methyl-xylocholine, an Adrenergic neuron blocker, inhibited the K-dependent response she had found in the cells.[2] This was unusual, as the Aplysia response she was researching was cholinergic and was not expected to change with the addition of an adrenergic inhibitor. From this data Kehoe determined that both the adrenergic and cholinergic responses she observed involved the same receptor.[2] She determined that multiple receptors for a particular neurotransmitter could be found on a neuron,[3] each receptor could change the conductance of the neurotransmitter in a different and independent manner, and that the postsynaptic response could vary from cell to cell.[2]

Kehoe then took a position as a full-time researcher at the

High Table at King's College. At the time High Table was all male—Kehoe was the first visiting female academic to be granted access.[2]

In the same year her husband Philippe accepted a teaching position in Paris, so that they could operate their own lab. Upon their return from Cambridge they were given space for their lab at

glutamate[2][11] receptors in the late 20th century. In 2002 she and Philippe gave up their lab to other researchers, and moved their research to the lab of their colleagues, Alain Marty and Isabel Llano, in another part of Paris.[2]
As of 2017 Kehoe continued researching neurotransmitters and their effects.

Personal life

In 1967 Kehoe married fellow researcher and French native Philippe Ascher. In the fall of 1968 she had her first son David. Her second son Ivan was born after she began working at Cold Spring. Until her death, she spent most of her life in Paris with her husband and their two children.

Works

References

  1. ^ "JacSue Kehoe (in memoriam)". www.sppin.fr. Retrieved 2020-01-07.
  2. ^
    ISBN 978-0-12-660246-3
    .
  3. ^ a b Kehoe 1972.
  4. ^ Kehoe 1963.
  5. ^
    ISBN 9781585626847
    .
  6. ISBN 9780199741472
    .
  7. ^ "JacSue Kehoe". wormbase.org. National Human Genome Research Institute.
  8. ISBN 9780521079426
    .
  9. ^ "Jones Building before and after Renovation - The Memory Board at Cold Spring Harbor Laboratory". libfe.cshl.edu. Retrieved 2016-11-29.
  10. PMID 18786366
    .
  11. ^ Kehoe & Vulfius 2000.
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