Johannes Buchner
Johannes Buchner is a German biochemist and professor at the
Technische Universität München, Munich, Germany.[1]
Career
Buchner obtained his PhD at the University of Regensburg, Germany, working with Rainer Rudolph and Rainer Jaenicke. He performed his postdoctoral research in the lab of Ira Pastan at the National Cancer Institute of the National Institutes of Health in Bethesda, USA, before becoming assistant professor at the University of Regensburg and subsequently full professor and Chair of Biotechnology at the TUM.
Research
Molecular
small heat shock proteins (sHsps), the Hsp90 chaperone machinery and the role of molecular chaperones in antibody folding. Buchner’s work established sHsps as molecular chaperones[4] and has significantly contributed to our understanding of their function and mode of activation.[5] His work on antibody folding delivered important insight in the mechanisms of how antibodies fold and are scrutinized by the cellular chaperone machinery.[6] A major focus of Johannes Buchner’s lab is the Hsp90 chaperone machine. His work has provided a detailed mechanistic understanding of Hsp90 and its regulation by co-chaperones, establishing a functional chaperone cycle for Hsp90, which has become a major target in cancer therapy[7][8]
Several discoveries from the Buchner lab on chaperone-mediated protein folding have been successfully translated into novel applications in biotechnology.
Memberships and awards
Buchner is a member of the
Medal (2017).References
- ^ "Startseite – Lehrstuhl für Biotechnologie". www.department.ch.tum.de. Retrieved 27 November 2021.
- OCLC 214281963.
- PMID 7913554.
- PMID 8093612.
- PMID 10581247.
- PMID 19524537.
- S2CID 31998513.
- S2CID 25210016.
- ^ CV Leopoldina
- ^ "The Protein Society: The home for the international protein science community". Archived from the original on 2016-03-05. Retrieved 2016-03-03.
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