Katherine Jones (academic)

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Katherine A. Jones
Alma materUniversity of California, Riverside
Known forHIV, stem cell biology, proteomics
Scientific career
InstitutionsSalk Institute for Biological Studies

Katherine A. Jones is a professor of

regulatory biology and the Edwin K. Hunter Chair at the Salk Institute for Biological Studies. She uses proteomics to study transcription elongation and molecular biology to understand protein coordination. Jones identified elongation factors
, a class of proteins which are important in viral gene expression.

Early life and education

Jones earned her PhD in

Sp1 binds to DNA and activates RNA.[3]

Research and career

Jones is a professor of

CycT1 is needed for normal cell function, so is not an ideal target for antivirals.[6]

Jones looks to create

SHMT2 and BRCC36, which subsequently enable the cells to destroy Tat.[9] At present JIB-04 is too toxic to primary T-cells, but Jones and colleagues are working on investigations of other small molecules that can still inhibit Tat expression.[9]

Jones demonstrated that in

colon cancer.[12] During their investigations of embryonic stem cells, Jones identified a third pathway, YAP, which slows the activin pathway and stops stem cells from specialising.[13] She used CRISPR-cas9 to remove the genes that make the YAP protein, reducing the number of steps to convert embryonic stem cells into functional heart cells.[13][14]

She has also studied the CDK12 gene, which is mutated in 3 - 5% of prostate, ovarian and breast cancers.[15] The majority of cancers that contain a mutated CDK12 gene are not responsive to immunotherapy, so creating inhibitors of CDK12 could make cancers more treatable.[15] When CDK12 is inhibited cells cannot repair DNA and the cells are more likely to die during chemotherapy.[15]

In 2017 Jones filed a lawsuit against the

gender discrimination, citing that their work had not been recognised their labs were small and they received less funding.[16][17] She claimed that imagery of women faculty members was used in Salk Institute promotional material to secure funding from donors.[16] Jones settled her case in August 2018.[18][19]

References

  1. ^ a b "Katherine Jones". Salk Institute for Biological Studies. Retrieved 2019-04-23.
  2. ^ "Katherine A. Jones, Ph.D." bit.ly. Retrieved 2019-04-23.
  3. ISSN 0968-0004
    .
  4. ^ "Katherine A. Jones". biology.ucsd.edu. Retrieved 2019-04-23.
  5. PMID 7979253
    .
  6. ^ a b c A new dent in HIV-1's armor, retrieved 2019-04-24
  7. ^ "Discovery reveals how cells try to control levels of key HIV protein". ScienceDaily. Retrieved 2019-04-24.
  8. S2CID 16395032
    .
  9. ^ a b "Small Molecule Appears to Destroy Protein That Wakes Dormant HIV". MD Magazine. Retrieved 2019-04-24.
  10. ^ Jones, Katherine. "Mechanism of beta-Catenin and APC-Regulated Transcription at Wnt Target Genes". Grantome.
  11. PMID 16510874
    .
  12. ^ Vital step in stem cell growth revealed, retrieved 2019-04-24
  13. ^ a b Getting straight to the heart of the matter in stem cells, retrieved 2019-04-24
  14. ^ "Salk Institute | The Stem Cellar". Retrieved 2019-04-24.
  15. ^ a b c "New role for a driver of metastatic cancers". EurekAlert!. Retrieved 2019-04-24.
  16. ^ a b Wadman, Meredith (2017-07-19). "Salk Institute under fire for 'smear' on women suing it for discrimination". Science | AAAS. Retrieved 2019-04-24.
  17. ISSN 0362-4331
    . Retrieved 2019-04-24.
  18. S2CID 81798888
    .
  19. ^ "Joint Statement from Salk President Dr. Rusty Gage, on behalf of the Salk Institute, and Salk Professors Drs. Kathy Jones and Vicki Lundblad". Salk Institute for Biological Studies. Retrieved 2019-04-24.
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