Keith R. Jerome
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Keith R. Jerome | |
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| Education | Georgetown College Duke University |
| Scientific career | |
| Fields | Virology |
| Institutions | University of Washington |
Keith R. Jerome is an American
Alexander Greninger shared the Washington Innovator of the Year award for developing the laboratory based assay for detecting COVID-19.[5] He was senior author on a research article published in Science describing the cryptic transmission of SARS-CoV-2 alongside Trevor Bedford, Alexander Greninger, Jay Shendure, and Helen Chu.[6] Regarding the origin of SARS-CoV-2 he reported that the live market in Wuhan was more likely than a lab leak of the virus.[7]
Jerome studies the ways in which these viruses evade the immune system and potential therapies for these infections. Jerome and his colleagues study the uses of precision gene-editing tools like
Herpes virus by using the DNA-cutting tools of gene therapy. Initial research showed these techniques could knock out small quantities of latent virus.[8] He and his colleagues are exploring this approach in combination with blood stem cell transplants as a means of curing HIV
.
Academic and medical appointments
- Professor, Department of Laboratory Medicine and Pathology, University of Washington, 2012–present
- Head, Virology Division, Laboratory Medicine, University of Washington, 2012–present
- Full professor, Fred Hutchinson Cancer Research Center, 2015–present
Education and training
- Georgetown College, B.S., Chemistry, summa cum laude, 1985
- Duke University, PhD, Microbiology and Immunology, 1992
- Duke University, MD, May 1993
- Resident Physician, Department of Pathology, University of Washington, 1993-1995
- Resident Physician, Department of Laboratory Medicine, University of Washington, 1995-1997
- Senior Fellow, Virology Division, Department of Laboratory Medicine, University of Washington, 1997-1998
Selected publications
- Jerome, Keith R.; Barnd, Donna L.; Bendt, Katharine M.; et al. (1991-06-01). "Cytotoxic T-Lymphocytes Derived from Patients with Breast Adenocarcinoma Recognize an Epitope Present on the Protein Core of a Mucin Molecule Preferentially Expressed by Malignant Cells". Cancer Research. 51 (11): 2908–2916.
- Jerome, Keith R.; Fox, Richard; Chen, Zheng; et al. (1999-11-01). "Herpes Simplex Virus Inhibits Apoptosis through the Action of Two Genes, Us5 and Us3". Journal of Virology. PMC 112926.
- Bhatraju, Pavan K.; Ghassemieh, Bijan J.; Nichols, Michelle; et al. (2020-05-21). "Covid-19 in Critically Ill Patients in the Seattle Region - Case Series". The New England Journal of Medicine (382): 2012–2022. PMC 7143164.
- Nalla, Arun K.; Casto, Amanda M.; Huang, Meei-Li W.; et al. (2020-05-26). "Comparative Performance of SARS-CoV-2 Detection Assays Using Seven Different Primer-Probe Sets and One Assay Kit". Journal of Clinical Microbiology. 58 (6). PMC 7269385.
- Joung, Julia; Ladha, Alim; Saito, Makoto; et al. (2020-09-16). "Detection of SARS-CoV-2 with SHERLOCK One-Pot Testing". New England Journal of Medicine. 383: 1492–1494. PMC 7510942.
- Bedford, Trevor; Greninger, Alexander L.; Roychoudhury, Pavitra; et al. (2020-09-10). "Cryptic transmission of SARS-CoV-2 in Washington state". Science. 370 (6516): 571–575. PMC 7276023.
- Perchetti, Garrett A.; Huang, Meei-Li; Mills, Margaret G.; Jerome, Keith R.; Greninger, Alexander L. (2021-02-18). "Analytical Sensitivity of the Abbott BinaxNOW COVID-19 Ag Card". Clinical Microbiology. 59 (3). PMC 8106729.
References
- PMID 32227758.
- ^ "How UW's Virology Lab Helped Forge the Nation's Covid-19 Testing". Seattle Met.
- ^ "When Coronavirus Struck Seattle, This Lab Was Ready To Start Testing". NPR.
- S2CID 212655031.
- ^ "Innovator of the Year awarded to directors of virology lab". newsroom.uw.edu. April 28, 2021.
- PMID 32913002.
- ^ "UW Medicine's head of Virology: Live market 'more likely the start' of COVID". MyNorthwest.com. November 28, 2021.
- ^ Russell, Sabin (2020-08-18). "A cure for herpes? There is progress to report". Fred Hutch. Retrieved 2022-04-03.
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