LILRA5
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Leukocyte immunoglobulin-like receptor subfamily A member 5 (LILR-A5) also known as CD85 antigen-like family member F (CD85f), immunoglobulin-like transcript 11 (ILT-11), and leukocyte immunoglobulin-like receptor 9 (LIR-9) is a
isoforms
have been described.
Function
The function of LILRA5 is currently unknown. However, it is highly homologous to other LILR genes, thus it is assumed to have similar functions to other LIR family members, i.e. activating and inhibitory functions in
proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses.[9][10]
Clinical significance
A recent genome-wide association study (GWAS) has found that genetic variations in LILRA5 are associated with late-onset sporadic Alzheimer’s disease (LOAD).[11]
LILBR2 plays a critical role in the inhibition of axonal regeneration and functional recovery after
cognitive impairment in Alzheimer's disease.[5][13] Due to its proximity to LILRB2, it is believed that LILRA5 mutation may also contribute to Alzheimer's disease.[11]
References
- ^ a b c ENSG00000274914, ENSG00000275404, ENSG00000187116, ENSG00000278355 GRCh38: Ensembl release 89: ENSG00000274113, ENSG00000274914, ENSG00000275404, ENSG00000187116, ENSG00000278355 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070873 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ S2CID 235203153.
- ^ "LILRA5 Gene - Leukocyte Immunoglobulin Like Receptor A5". Gene Cards. Retrieved 2021-12-11.
- ^ "LILRA5 leukocyte immunoglobulin like receptor A5 [Homo sapiens (human)]". Gene - NCBI. National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 2021-12-11.
- S2CID 38450831.
- S2CID 34746237.
- S2CID 221180491.
- ^ S2CID 237442349.
- PMID 28676756.
- PMID 24052308.