Lary Walker
Lary Craswell Walker | |
|---|---|
| Born | Alexander von Humboldt Research Award (2016)[3] Peter Bassoe Lectureship of the American Neuropsychiatric Association (2017)[4] |
| Scientific career | |
| Fields | |
| Institutions | Tulane University Emory University Johns Hopkins University University of Greifswald Parke-Davis/Warner-Lambert University of Tübingen |
Lary Walker is an American
Atlanta, Georgia. He is Associate Director of the Goizueta Alzheimer's Disease Research Center at Emory,[5] and he is known for his research on the role of abnormal proteins in the causation of Alzheimer's disease.[1][6]
Education and career
Walker received his Bachelor of Science degree from Louisiana State University, and his Master of Science and PhD degrees from Tulane University. Following a German Academic Exchange (DAAD) Fellowship at the University of Kassel and a National Institutes of Health (NIH) postdoctoral fellowship at Emory University, he moved to the Neuropathology Laboratory of Donald L. Price at Johns Hopkins University, where he began work on the biological basis of Alzheimer's disease.[7][8] In 1995 he became head of the Alzheimer's disease drug discovery program at Parke-Davis/Warner-Lambert in Ann Arbor, Michigan. In 2003 he returned to Emory University, where he is the Marie and E.R. Snelling Professor of Neurology.[9][10]
Research
Biology of Aβ (senile) plaques
Walker's early research established that a variety of
animal models of Alzheimer's disease, Walker has proposed that humans are uniquely vulnerable to Alzheimer's disease.[16][17][18]
Prion-like properties of disease-causing proteins
Since the late 1990s, Walker's research has been directed toward the mechanisms that drive the misfolding and aggregation of the Aβ protein in the living brain. In collaboration with
Awards
Walker received the
Alexander von Humboldt Research Award in 2016,[3] and the Peter Bassoe Lectureship of the American Neuropsychiatric Association in 2017.[4]
Bibliography
Selected reviews
- "Seeds of Dementia". Walker LC and Jucker M (2013). Scientific American 308: 52-57; PMID 23627220.
- "Mechanisms of protein seeding in neurodegenerative diseases" Walker LC, Diamond MI, Duff KE and Hyman BT (2013). JAMA Neurology 70: 304-310; PMID 23599928, PMCID: PMC3665718.
- "Self-propagation of pathogenic protein aggregates in neurodegenerative diseases". Jucker M and Walker LC (2013). Nature 501: 45-51; PMID 24005412, PMCID: PMC3963807.
- "Neurodegenerative diseases: Expanding the prion concept". Walker LC and Jucker M (2015). Annual Review of Neuroscience 38: 87-103; PMID 25840008, PMCID: PMC4803040.
- "Proteopathic strains and the heterogeneity of neurodegenerative diseases". Walker LC (2016). Annual Review of Genetics 50: 329-346; PMID 27893962, PMCID: PMC6690197.
- "Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases". Jucker M, Walker LC (2018). Nature Neuroscience 21: 1341-1349; PMID 30258241, PMCID: PMC6375686.
Selected research reports
- "Augmented senile plaque load in aged female β-amyloid precursor protein transgenic mice". Callahan MJ, Lipinski WJ, Bian F, Durham RA, Pack A and Walker LC (2001). American Journal of Pathology 158: 1173-1177; PMID 11238065, PMCID: PMC1850367.
- "Exogenous induction of Aβ-amyloidogenesis is governed by intrinsic properties of agent and host". Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL, Vigouret J, Paganetti P, Walsh DM, Mathews P, Ghiso J, Staufenbiel M, Walker LC and Jucker M (2006). Science 313: 1781-1784; PMID 16990547.
- "Deficient high-affinity binding of Pittsburgh Compound B in a case of Alzheimer's disease". Rosen RF, Ciliax BJ, Gearing M, Dooyema J, Wingo T, Lah JJ, Ghiso JA, LeVine III H and Walker LC (2010). Acta Neuropathologica 119: 221-233; PMID 19690877, PMCID: PMC3045810.
- "Exogenous seeding of cerebral β-amyloid deposition in βAPP-transgenic rats". Rosen RF, Fritz JJ, Dooyema J, Cintron AF, Hamaguchi T, Lah JJ, LeVine III H, Jucker M and Walker LC (2012). Journal of Neurochemistry 120: 660-666; PMID 22017494, PMCID: PMC3293176.
- "Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease". Rasmussen J, Mahler J, Beschorner N, Kaeser SA, Häsler LM, Baumann F, Nyström S, Portelius E, Blennow K, Lashley T, Fox NC, Sepulveda-Falla D, Glatzel M, Oblak AL, Ghetti B, Nilsson KPR, Hammarström P, Staufenbiel M, Walker LC and Jucker M (2017). Proceedings of the National Academy of Sciences USA 114: 13018-13023; PMID 29158413, PMCID: PMC5724274.
Complete list of published work
- https://scholar.google.com/citations?user=Ap8lgXEAAAAJ&hl=en&oi=sra
- http://www.ncbi.nlm.nih.gov/sites/myncbi/1feivrkCu97Q5/bibliography/41295477/public/?sort=date&direction=descending
Selected book chapters
- "The neurobiology of aging in nonhuman primates". Walker LC and Cork LC (1999). In: Alzheimer Disease (ISBN 0781715032), RD Terry, R Katzman, KL Bick and SS Sisodia, Eds., Lippincott Williams and Wilkins, Philadelphia, PA, pp 233-243.
- "Pathogenic protein strains as diagnostic and therapeutic targets in Alzheimer's disease". Walker LC, Rosen RF and LeVine III H (2012). In: Alzheimer's Disease: Targets for New Clinical Diagnostic and Therapeutic Strategies (ISBN 978-1-4398-2708-6), R Wegrzyn and AS Rudolph, Eds., CRC Press, Boca Raton, FL, pp 231-247.
- "The prion-like properties of amyloid-β assemblies: Implications for Alzheimer's disease". Walker LC, Schelle J and Jucker M (2017). In: Prion Diseases (ISBN 978-1-621820-10-9), SB Prusiner, Ed., Cold Spring Harbor Laboratory Press, pp 175-188.
- "Prion-like protein seeding and the pathobiology of Alzheimer's disease". Walker LC (2018). In: Protein Folding Disorders in the Central Nervous System (ISBN 978-981-3222-95-3), J. Ghiso and A. Rostagno, Eds., World Scientific Publishing Company, pp 57-82.
References
- ^ a b c "MetLife Foundation Awards for Medical Research in Alzheimer's Disease" (PDF). Archived from the original (PDF) on 13 October 2018.
- ^ "2014 MetLife Foundation Awards". YouTube.
- ^ a b "Alexander von Humboldt Foundation".
- ^ a b "American Neuropsychiatric Association Annual Meeting 2017".
- ^ "Emory Goizueta ADRC Faculty and Staff".
- ^ PMID 19965731.
- ^ "ORCID iD Lary Walker".
- S2CID 26512854.
- ^ "Emory Neurology Faculty".
- ^ "Emory Medicine Dean's Letter September 2016".
- S2CID 25208183.
- S2CID 201656098.
- PMID 9058061.
- S2CID 22652110.
- S2CID 38283117.
- PMID 28483344.
- PMID 31871211.
- ^ "Is Alzheimer's Disease a Uniquely Human Disorder?".
- PMID 24005412.
- S2CID 46357173.
- S2CID 54314137.
- PMID 20234357.
- PMID 25261551.
- PMID 31641070.
External links
- Seeded Aggregation and Transmissible Proteopathy—Creepy Stuff Not Just for Prions Anymore? Retrieved 2020-04-16.
- Abnormal proteins and Alzheimer's disease Retrieved 2020-04-16.
- Die Saat des Vergessens (Article on prion-like protein seeding in Alzheimer's disease) Retrieved 2020-04-15.
- Evidence of a 'transmissible' Alzheimer's protein Retrieved 2020-04-16.
- Zwei Schritte vor, einen zurück (Article on the halting progress toward treatments for Alzheimer's disease) Retrieved 2020-04-15.
- Q&A with Lary C. Walker, Ph.D. Retrieved 2020-05-04.
- Protein Misfolding Diseases with Dr. Lary Walker Retrieved 2020-05-04.
- Alzheimer's, An Infectious Disease? Retrieved 2020-05-04.
- How do Neurodegenerative Diseases Progress? Retrieved 2020-05-04.
- Treatment from Brain Tissue May have Spread Alzheimer's Protein Retrieved 2020-05-04.
- Corrupted Proteins Spread Disease Retrieved 2020-05-04.
- Alzheimer's alphabet Retrieved 2020-05-04.
