Lexitropsin
Lexitropsins are members of a family of
semi-synthetic DNA-binding ligands.[1] They are structural analogs of the natural antibiotics netropsin and distamycin. Antibiotics of this group can bind in the minor groove of DNA with different sequence-selectivity.[2][3] Lexitropsins form a complexes with DNA with stoichiometry 1:1 and 2:1. Based on the 2:1 complexes were obtained ligands with high sequence-selectivity.[4]
See also
- Hoechst 33258
- Pentamidine
- DNA binding ligand
- Single-strand binding protein
- Comparison of nucleic acid simulation software