Lipopeptide

agonists.^[3] Certain lipopeptides can have strong antifungal and hemolytic activities.^[9] It has been demonstrated that their activity is generally linked to interactions with the plasma membrane,^[10] and sterol components of the plasma membrane could play a major role in this interaction.^[11][12] It is a general trend that adding a lipid group of a certain length (typically C10–C12) to a lipopeptide will increase its bactericidal activity.^[13] Lipopeptides with a higher amount of carbon atoms, for example 14 or 16, in its lipid tail will typically have antibacterial activity as well as anti-fungal activity.^[13] Therefore, an increase in the alkyl chain can make lipopeptides soluble in water.^[7] As well, it opens the cell membrane of the bacteria, so antimicrobial activity can take place.^[14]