Lipopeptide
| Cyclic lipopeptide antibiotics | |
|---|---|
| Identifiers | |
| Symbol | N/A |
TCDB | 1.D.15 |
| OPM superfamily | 163 |
| OPM protein | 1t5n |
A lipopeptide is a
agonists.[3] Certain lipopeptides can have strong antifungal and hemolytic activities.[9] It has been demonstrated that their activity is generally linked to interactions with the plasma membrane,[10] and sterol components of the plasma membrane could play a major role in this interaction.[11][12] It is a general trend that adding a lipid group of a certain length (typically C10–C12) to a lipopeptide will increase its bactericidal activity.[13] Lipopeptides with a higher amount of carbon atoms, for example 14 or 16, in its lipid tail will typically have antibacterial activity as well as anti-fungal activity.[13] Therefore, an increase in the alkyl chain can make lipopeptides soluble in water.[7] As well, it opens the cell membrane of the bacteria, so antimicrobial activity can take place.[14]
Lipopeptide detergents (LPDs) are composed of amphiphiles and two alkyl chains which are located on the last part of the peptide backbone. They were designed to mimic the architecture of the native membranes in which two alkyl chains in a lipid molecule facially interact with the hydrophobic segment of MPs.[15]
Examples
- Bacillomycin
- Daptomycin
- Echinocandins (e.g., caspofungin)
- Iturin A
- Mycosubtilin
- Surfactin
See also
- GPCRs.
References
- ^ PMID 25797909.
- S2CID 44681934.
- ^ PMID 25382300.
- PMID 28636078.
- ^ US granted 6911525, Hill J, et al., "Lipopeptides as antibacterial agents", published 28 February 2002, assigned to Cubist Pharmaceuticals Inc
- PMID 15705644.
- ^ .
- PMID 20412310.
- PMID 8160184.
- ^ Nasir MN, Besson F, Deleu M (September 2013). "Interactions des antibiotiques ituriniques avec la membrane plasmique. Apport des systèmes biomimétiques des membranes (synthèse bibliographique)". Biotechnologie, Agronomie, Société et Environnement. 17 (3): 505–16.
- PMID 22306791.
- PMID 21766869.
- ^ PMID 25632392.
- PMID 26170198.
- ISBN 978-0-08-100736-5.
Further reading
- Giuliani A, Pirri G, Nicoletto S (2007). "Antimicrobial peptides: an overview of a promising class of therapeutics". Cent. Eur. J. Biol. 2 (1): 1–33. .
- Pirri G, Giuliani A, Nicoletto S, Pizutto L, Rinaldi A (2009). "Lipopeptides as anti-infectives: a practical perspective" (PDF). Cent. Eur. J. Biol. 4 (3): 258–273. .