List of immunofluorescence findings for autoimmune bullous conditions

Source: Wikipedia, the free encyclopedia.

Several cutaneous conditions can be diagnosed with the aid of immunofluorescence studies.

Cutaneous conditions with positive direct or indirect immunofluorescence when using salt-split skin include:

Antibody isotype(s) and location of antibody deposition in immunofluorescence studies using salt-split skin for autoimmune bullous conditions targeting the basement membrane zone of the human integumentary system
Condition Antibody isotype(s) deposited Localization of antibody with use of salt-split skin
Antiepilegrin cicatricial pemphigoid
IgG Dermal
Bullous lupus erythematosus
Dermal
Bullous pemphigoid IgG Epidermal
Cicatricial pemphigoid
IgG Epidermal
Epidermolysis bullosa acquisita IgG Dermal
Linear IgA bullous dermatosis
IgA
Epidermal
Orf-induced immunobullous disease
IgG Dermal
Pemphigoid gestationis
IgG Epidermal

For several subtypes of pemphigus a variety of substrates are used for indirect immunofluorescence:

Substrates used in indirect immunofluorescence studies for the different pemphigus variants
Pemphigus variant Substrate
Pemphigus foliaceous
Guinea pig esophagus
Pemphigus vulgaris Monkey esophagus
IgA pemphigus Cultured skin
Paraneoplastic pemphigus Rat bladder

See also

References

  • Bolognia, Jean L.; et al. (2007). Dermatology. St. Louis: Mosby. .
  • James, William D.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. .