Medical experimentation in Africa

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African countries have been sites for clinical trials by large pharmaceutical companies, raising human rights concerns.[1] Incidents of unethical experimentation, clinical trials lacking properly informed consent, and forced medical procedures have been claimed and prosecuted.

Specific incidents by date

Meningitis testing in Nigeria: 1990s

The Pfizer drug

Trovan was used in a clinical trial in Kano, Nigeria. The trial compared the new antibiotic (Trovan) against the best treatment available at the time (intravenous ceftriaxone). Eleven children died in the trial: five after taking Trovan and six after taking an older antibiotic used for comparison in the clinical trial. Others suffered blindness, deafness and brain damage, the cause of which is difficult to determine because these disabilities are relatively common outcomes of the disease itself. A panel of medical experts later implicated Pfizer in the incident, concluding the drug had been administered as part of an illegal clinical trial without authorization from the Nigerian government or consent from the children's parents. This led to a lawsuit from the Nigerian government over informed consent.[2][3] Pfizer countered that it met all the necessary regulations.[2] The drug was approved for general use in the US but eventually withdrawn due to hepatotoxicity
.

HIV/AIDS testing in Zimbabwe: 1990s

under duress.[4] Half of these women received a placebo that has no effect, making transmission likely. As a result, an estimated 1000 babies contracted HIV/AIDS although a proven life-saving regimen already existed.[4] The CDC ended the short course testing in 1998 after they announced they had enough information from Thailand trials.[4]

Forced sexual reassignment in South Africa: 1970s–1980s

In a project headed by Aubrey Levin during the 1970s to 1980s, the South African Defence Force forced lesbian and gay military personnel to undergo "sex-change" operations. This was part of a secret program to purge homosexuality in the army.[citation needed] It included psychological coercion, chemical castration, electric shock, and other unethical medical experiments. An estimated 900 forced sexual reassignment operations may have been performed between 1971 and 1989 at military hospitals.[citation needed] Most of the victims were males, young 16 to 24-year-old white men who were drafted into the army during the South African Border War. Women were also subject to the experimentation.[citation needed]

Forced contraception in Rhodesia (now Zimbabwe): 1970s

Depo-Provera was clinically tested on black Rhodesian (now Zimbabwean) women in the 1970s.[1] Once approved, the drug was used as a birth control measure. Women on white-run commercial farms were coerced into accepting Depo-Provera.[5] In 1981, the drug was banned in what was by then Zimbabwe.[5]

Sterilisation experiments in German South-West Africa (now part of Namibia): Late 1800s–1910s

]

Effects on legitimate medicine

Unethical medical experimentation that has occurred for over a century may be the cause of the documented fear and mistrust of doctors and medicine in Africa.[8] For example, polio has been on the rise in Nigeria, Chad, and Burkina Faso because many people there avoid vaccinations because they believe that the vaccines are contaminated with HIV or sterilization agents.[8] Due to the meningitis testing incident in Kano, many Nigerians now refuse to participate in clinical trials.[2]

The role of poverty

Many African nations cannot afford to offer medicine for their citizens without subsidies from multinational pharmaceutical corporations.[4] To court these pharmaceutical corporations, some African nations minimize legal regulations on the conduct of medical research, which prevents potential legal battles from arising.[4] This forces some Africans to make a Hobson's choice: "experimental medicine or no medicine at all".[9] People living in the rural or slum area are also more vulnerable to experimentation because they are more likely to be illiterate and to misunderstand the effects of the experimentation.[10]

Codes of ethics

Several national and international bodies have devised codes of ethics for conducting experiments and clinical trials. These include the

Protocol to the African Charter on Human and Peoples' Rights on the Rights of Women in Africa, which seeks to prohibit all medical and scientific experiments on women without their prior informed consent.[11]

Popular culture references

The

New York Times best seller book Medical Apartheid by Harriet A. Washington, provides a historical account of experimentation on African Americans, but also includes the links to African experimentation.[2]

See also

References

  1. ^
    Anchor Books
    2006 p390
  2. ^ a b c d Washington, Harriet A. Medical Apartheid, Anchor Books 2006 p392-393
  3. ^ "Africa | Nigeria sues drugs giant Pfizer". BBC News. 2007-06-05. Retrieved 2010-11-12.
  4. ^ a b c d e f g h Meier, Benjamin Mason: International Protection of Persons Undergoing Medical Experimentation: Protecting the Right of Informed Consent, Berkeley Journal of International Law [1085-5718] Meier yr:2002 vol:20 iss:3 pg:513 -554
  5. ^ a b Kaler, Amy. 1998. "A Threat to the Nation and a Threat to the Men: the Banning of Depo-Provera in Zimbabwe, 1981". Journal of Southern African Studies 24(2):p 347
  6. ^ "Herero and Namaqua Genocide - Herero Genocide Nama Genocide". Archived from the original on 2011-12-09. Retrieved 2011-11-28.
  7. ^ Eugen Fischer
  8. ^ a b Washington, Harriet A. (2007-07-31). "Why Africa Fears Western Medicine". The New York Times.
  9. ^ Washington, Harriet A. Medical Apartheid, Anchor Books 2006 p394
  10. S2CID 24491268
    . Retrieved 2010-11-12.
  11. ^ "allAfrica.com: Africa: Women And Scientific Experiments - Is Informed Consent Enough? (Page 1 of 3)". Archived from the original on 2008-05-31.