Muscarinic toxin 2
| Muscarinic toxin 2 | |
|---|---|
Muscarinic toxin 2 (MT2) is one member of a family of small
synapses
.
The interactions of muscarinic toxins studied using N-methyl scopolamine (NMS) with human muscarinic receptor subtypes m1, m2, m3 and m4 has shown that MT2 and the related MT1 toxin are specific for M1 (Ki=630 nM)[2] and M4 (Ki=1900 nM)[2] receptors, but have little effect on binding to M2 and M3 receptors. The interaction at M1 receptors appears to be essentially irreversible like for muscarinic toxin 7
.
References
- ^ Menez R, Le Du MH, Gaucher JF, Menez A. "X-ray structure of muscarinic toxin 2 at 1.5 Angstrom resolution".
{{cite journal}}: Cite journal requires|journal=(help) - ^ PMID 11086210.