Nuclear transfer
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Nuclear transfer is a form of
Despite this, the low efficiency of the technique has prompted some researchers, notably Ian Wilmut, creator of Dolly the cloned sheep, to abandon it.[4]
Tools and reagents
Nuclear transfer is a delicate process that is a major hurdle in the development of cloning technology.
Various chemical reagents are used to increase cloning efficiency.
Somatic cell nuclear transfer
Reprogramming
Genomic reprogramming is the key biological process behind nuclear transfer. Currently unidentified reprogramming factors present in oocytes are capable of initiating a cascade of events that can reset the mature, specialized cell back to an undifferentiated, embryonic state. These factors are thought to be mainly proteins of the nucleus.
See also
- Induced stem cells
- Renucleation
- three-parent baby#Ethics
References
- PMID 29395327.
- ^ Briggs, Helen (24 January 2018). "First monkey clones created in Chinese laboratory". BBC News. Retrieved 24 January 2018.
- ^ "Scientists Successfully Clone Monkeys; Are Humans Up Next?". The New York Times. Associated Press. 24 January 2018. Retrieved 24 January 2018.
- ^ Roger Highfield Dolly creator Prof Ian Wilmut shuns cloning. The Telegraph. 16 November 2007
- ^ "PNAS Classics -- Nuclear Transfer". www.pnas.org. Archived from the original on 2003-11-21.
- PMID 23683578.