Organelle biogenesis
Organelle biogenesis is the
Discovery
Following the discovery of cellular organelles in the nineteenth century, little was known about their function and
Mechanisms of protein sorting and retrieval have been found to give organelles their characteristic composition. It is known that cellular organelles can come from preexisting organelles; however, it is a subject of controversy whether organelles can be created without a preexisting one.[1]
Process
Several processes are known to have developed for organelle biogenesis. These can range from de novo synthesis to the copying of a template organelle; the formation of an organelle 'from scratch' and using a preexisting organelle as a template to manufacture an organelle, respectively. The distinct structures of each organelle are thought to be caused by the different mechanisms of the processes which create them and the proteins that they are made up of. Organelles may also be 'split' between two cells during the process of cellular division (known as organelle inheritance), where the organelle of the parent cell doubles in size and then splits with each half being delivered to their respective daughter cells.[1][2]
The process of organelle biogenesis is known to be regulated by specialized transcription networks that modulate the expression of the
Several metabolic diseases are known to be caused by a fault in the process of organelle biogenesis. These may include mitochondrial biogenesis defects, peroxisome biogenesis disorders, and lysosomal storage disorders.[3]
References
- ^ ISBN 978-0-306-47990-8.
- S2CID 7716912.
- ^ PMID 16103713.