Paul M. Bingham
Paul Montgomery Bingham (born February 25, 1951) is an American
Biography
Bingham received his undergraduate degree at
Molecular biology
He was part of a collaborative team that discovered the
With his wife (Zuzana Zachar), he demonstrated that
His research group also worked on the nature of metazoan gene regulation
Bingham and Zachar discovered the first-in-class anti-cancer mitochondrial metabolism drug (CPI-613; devimistat),[19] currently in Phase III registrational clinical trials in pancreatic ductal adenocarcinoma and acute myeloid leukemia.[20] This work is now being done in collaboration with Rafael Pharmaceuticals.[19]
Human evolutionary biology
In the mid-1990s, he developed a theory of human uniqueness that proposes a novel explanation of why humans have evolved to be ecologically dominant. The theory has been published in three peer-reviewed journals:
He and co-author Joanne Souza have developed the theory further in a self-published book,
The theory, using precedents established in biological theory, proposes to explain many aspects of human social and sexual behavior. It proposed to account for the evolution of the human species from the advent of its phylogenetic branching from other hominins through physiological and behavioral adaptations until our current civilization.[25] This theory of human uniqueness claims to answer the fundamental scientific challenge posed by Charles Darwin, to explain the descent of man: how did the 'incremental' process of evolution by natural selection suddenly produce an utterly unprecedented kind of animal, humans? It suggests an explanation of human origins, and also of human properties (from speech to political/economic/religious behavior).[26]
According to his theory, the cost to an enforcer of coercing a cheating individual into a cooperative effort, known as the
The theory further generalizes to a theory of history,
Academic work
In collaboration with Joanne Souza, he has developed a course [1] on the logic and implications of this new theory [2].
Bingham has served as the Faculty Director of the Freshmen College of Human Development at Stony Brook [3].
Bingham also serves on the management team of Rafael Pharmaceuticals, a firm developing cancer therapies, as Vice President of Research. He and his collaborator, Prof. Zuzana Zachar, recently received the Maffetone Research Prize from the Carol M. Baldwin Breast Cancer Research Fund for their cancer work.[1][19]
Publications
Social coercion theory
- Bingham PM (1999). "Human uniqueness: A general theory". Quarterly Review of Biology. 74 (2): 133–169. S2CID 59499229.
- Bingham PM (2000). "Human evolution and human history: A complete theory". Evolutionary Anthropology. 9 (6): 248–257. .
- Souza J, Bingham PM (2019). "Chapter 7: The New Human Science: Sound, New Evolutionary Theory Gives Us Ultimate Causal Understanding of Human Origins, Behavior, History, Politics, and Economics". In Geher G, Wilson DS, Gallup A, Head H (eds.). Darwin's roadmap to the curriculum: evolutionary studies in higher education. New York, NY. pp. 117–156. ISBN 978-0-19-062496-5.)
{{cite book}}
: CS1 maint: location missing publisher (link - Souza J, Bingham PM (2014). "Disciplinary unification of the Natural Sciences, the Humanities, and the Social Sciences: Adapted minds and strategic approaches to consilience in the Academy" (PDF). EvoS Journal: The Journal of the Evolutionary Studies Consortium. 6 (1): 51–62.
- Yumpu.com. "Theoretical Contribution - the EvoS Consortium!". yumpu.com. Retrieved 2021-04-22.
- Bingham PM, Souza J (2013). "Theory testing in prehistoric North America: fruits of one of the world's great archeological natural laboratories". Evolutionary Anthropology. 22 (3): 145–53. S2CID 26024208.
- Bingham PM, Souza J, Blitz JH (May 2013). "Introduction: social complexity and the bow in the prehistoric North American record". Evolutionary Anthropology. 22 (3): 81–8. S2CID 25793489.
- Bingham P. "Ultimate causation in evolved human political psychology: implications for public policy" (PDF). APA PsycNet.
- Bingham PM (2010). "On the evolution of language: implications of a new and general theory of human origins, properties, and history". In Yamakido H, Larson RK, Déprez V (eds.). The Evolution of Human Language: Biolinguistic Perspectives. Approaches to the Evolution of Language. Cambridge: Cambridge University Press. pp. 211–224. ISBN 978-0-521-51645-7. Retrieved 2021-04-22.</ref>
Cancer research
- Alistar A, Morris BB, Desnoyer R, Klepin HD, Hosseinzadeh K, Clark C, et al. (June 2017). "Safety and tolerability of the first-in-class agent CPI-613 in combination with modified FOLFIRINOX in patients with metastatic pancreatic cancer: a single-centre, open-label, dose-escalation, phase 1 trial". The Lancet. Oncology. 18 (6): 770–778. PMID 28495639.
- Stuart SD, Schauble A, Gupta S, Kennedy AD, Keppler BR, Bingham PM, Zachar Z (March 2014). "A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process". Cancer & Metabolism. 2 (1): 4. PMID 24612826.
- Zachar Z, Marecek J, Maturo C, Gupta S, Stuart SD, Howell K, et al. (November 2011). "Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo". Journal of Molecular Medicine. 89 (11): 1137–48. S2CID 21925478.
- Bingham PM, Stuart SD, Zachar Z (November 2014). "Lipoic acid and lipoic acid analogs in cancer metabolism and chemotherapy". Expert Review of Clinical Pharmacology. 7 (6): 837–46. S2CID 7927805.
References
- ^ a b c "Biochemistry faculty profile". SUNY Stonybrook. Retrieved 18 March 2017.
- ^ "Paul Bingham, Ph.D.Vice President of Research". Rafael Pharmaceuticals. Archived from the original on 23 February 2021. Retrieved 23 February 2021.
- ^ "Paul Bingham". World Science Festival. Retrieved 2021-04-22.
- ^ a b "Paul Bingham | SUNY: Stony Brook University - Academia.edu". sbsuny.academia.edu. Retrieved 2021-04-22.
- ^ "2012-13 ALLELE Series". ALLELE Seminar Series. Retrieved 2021-04-22.
- S2CID 25146339.
- S2CID 10025372.
- S2CID 18723067.
- ^ PMID 2542025.
- S2CID 1985358.
- PMID 2544017.
- PMID 2832151.
- PMID 3443103.
- PMID 2853467.
- PMID 7971282.
- S2CID 20307555.
- PMID 8491768.
- PMID 14731863.
- ^ a b c "Executive Management Team". Rafael Pharmaceuticals. Retrieved 2021-04-22.
- ^ "Rafael cornerstone starts phase III pancreatic trial; CPI-613 in AML study, too". www.bioworld.com. Retrieved 2021-04-22.
- PMID 18462758.
- S2CID 59499229.
- ISBN 978-1-4392-5412-7.
- ^ S2CID 26024208.
- ^ ISSN 0033-5770.
- ISBN 978-0-262-52666-1.
- S2CID 1567228.
- .
- ^ niallmck1 (24 January 2021). "Self-Interested or Super-Cooperators? Human Nature from an Evolutionary Perspective". The Weekend University. Retrieved 2021-04-22.
{{cite web}}
: CS1 maint: numeric names: authors list (link) - S2CID 25793489.
- ^ Poe M, Bingham P, Souza J (2010-04-30). "P. Bingham and J. Souza, "Death From a Distance and the Birth of a Humane Universe"". New Books Network. Archived from the original on November 28, 2011.
- .