Population impact measure
Population impact measures (PIMs) are biostatistical measures of risk and benefit used in epidemiological and public health research. They are used to describe the impact of health risks and benefits in a population, to inform health policy.[1][2][3]
Frequently used measures of risk and benefit identified by Jerkel, Katz and Elmore,
They are measures of absolute risk and benefit, producing numbers of people who will benefit from an intervention or be at risk from a risk factor within a particular local or national population.[5][6][7][8][9][10] They provide local context to previous measures, allowing policy-makers to identify and prioritise the potential benefits of interventions on their own population.[11][12] They are simple to compute, and contain the elements to which policy-makers would have to pay attention in the commissioning or improvement of services. They may have special relevance for local policy-making. They depend on the ability to obtain and use local data, and by being explicit about the data required may have the added benefit of encouraging the collection of such data.
Measures
To describe the impact of preventive and treatment interventions, the number of events prevented in a population (NEPP) is defined as "the number of events prevented by the intervention in a population over a defined time period". NEPP extends the well-known measure
The components for the calculations are as follows: population denominator (size of the population); proportion of the population with the disease; proportion of the population exposed to the risk factor or the incremental proportion of the diseased population eligible for the proposed intervention (the latter requires the actual or estimated proportion who are currently receiving the interventions 'subtracted' from best practice goal from guidelines or targets, adjusted for likely compliance with the intervention); baseline risk – the probability of the outcome of interest in this or similar populations; and relative risk of outcome given exposure to a risk factor or relative risk reduction associated with the intervention.[citation needed]
NEPP
The formula for calculating the NEPP is
where
- N = population size,
- Pd = prevalence of the disease,
- Pe = proportion eligible for treatment,
- ru = risk of the event of interest in the untreated group or baseline risk over appropriate time period (this can be multiplied by life expectancy to produce life-years),
- RRR = relative risk reduction associated with treatment.
In order to reflect the incremental effect of changing from current to 'best' practice, and to adjust for levels of compliance, the proportion eligible for treatment, Pe, is , where Pt is the proportion currently treated, Pb is the proportion that would be treated if best practice were adopted, and Pc is the proportion of the population who are compliant with the intervention.
[Note: number needed to treat (NNT): 1/(baseline risk x relative risk reduction)]
PIN − ER − t
The formula for calculating the PIN − ER − t is
where
- N is the number of people in the population;
- Ip is the baseline risk of the outcome of interest in the population as a whole;
- t is the amount of time over which the outcome is measured.
The PAR/F, population attributable risk (or fraction), is calculated for two or multiple strata. The basic formula to compute the PAR for dichotomous variables is
where
- Pe is the prevalence of the population within each income stratum as the exposure, and
- RR is the prevalence of risk factors in each stratum relative to the highest income fifth.
This is modified where there are multiple strata to:
References
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- ^ Jekel JF, Katz DL, Elmore JG Epidemiology, biostatistics, and preventive medicine: Chapter 6 Assessment of risk and benefit in epidemiologic studies Elsevier Health Sciences, 2001[page needed]
- PMID 19001458.
- PMID 17181867.
- PMID 16553956.
- PMID 16286491.
- PMID 17074870.
- ^ Syed AM, Talbot-Smith A, Gemmell I. The use of epidemiological measures to estimate the impact of primary prevention interventions on CHD, stroke and cancer outcomes: experiences from Herefordshire, UK. J Epidemiol Glob Health. 2012 Sep;2(3):111-24.
- PMID 20418545.
- PMID 16774292.