Positional sequencing
Positional sequencing is a method of
A collection of maps may be used to reconstruct single-base resolved sequence in a process analogous to sequence reconstruction in sequencing by hybridization. Ambiguities in the reconstruction of sequences are resolved through the knowledge of the relative position of overlapping sequence specific recognition events. By varying the parameters (e.g., length of read, density of recognition events, resolution of the detector) governing a specific implementation of the method, it is possible to query all size scales of DNA variation, from single nucleotide sequence all the way to large structural variants and chromosomal aneuploidies.[1][2]
See also
References
- ^ a b Heger, Monica (2012-01-17). "Nabsys Develops 'Positional Sequencing' Tech for Assembly, Whole-Genome Mapping, Targeted Sequencing". GenomeWeb - In Sequence. Archived from the original on January 23, 2012. Retrieved 2012-01-30.
{{cite news}}: CS1 maint: unfit URL (link) - ^ Oliver; John S.; et al. "US Patent Application 20070190542". Retrieved 31 January 2012.
{{cite web}}: CS1 maint: multiple names: authors list (link)
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