Pulsatile flow

In

pumping the fluid.

Equation

The pulsatile flow profile is given in a straight pipe by

${\displaystyle u(r,t)=\mathrm {Re} \left\{\sum _{n=0}^{N}{\frac {i\,P'_{n}}{\rho \,n\,\omega }}\left[1-{\frac {J_{0}(\alpha \,n^{1/2}\,i^{3/2}\,{\frac {r}{R}})}{J_{0}(\alpha \,n^{1/2}\,i^{3/2})}}\right]e^{in\omega t}\right\}\,,}$

where:

u	is the longitudinal flow velocity,
r	is the radial coordinate ,
t	is time,
α	is the dimensionless Womersley number ,
ω	is the oscillatory pressure gradient ,
n	are the natural numbers ,
P'n	is the pressure gradient magnitude for the frequency nω,
ρ	is the fluid density ,
μ	is the dynamic viscosity ,
R	is the pipe radius,
J0(·)	is the Bessel function of first kind and order zero,
i	is the imaginary number, and
Re{·}	is the real part of a complex number .

Properties

Womersley number

The pulsatile flow profile changes its shape depending on the Womersley number

${\displaystyle \alpha =R\left({\frac {\omega \rho }{\mu }}\right)^{1/2}\,.}$

For ${\displaystyle \alpha \lesssim 2}$, viscous forces dominate the flow, and the pulse is considered

with a parabolic profile. For ${\displaystyle \alpha \gtrsim 2}$, the inertial forces are dominant in the central core, whereas viscous forces dominate near the boundary layer. Thus, the velocity profile gets flattened, and phase between the pressure and velocity waves gets shifted towards the core.^{[citation needed]}

Function limits

Lower limit

The Bessel function at its lower limit becomes^[2]

${\displaystyle \lim _{z\to \infty }J_{0}(z)=1-{\frac {z^{2}}{4}}\,,}$

which converges to the

profile for steady flow for

${\displaystyle \lim _{n\to 0}u(r,t)=-{\frac {P'_{0}}{4\mu }}\left(R^{2}-r^{2}\right)\,,}$

or to a

pulse with parabolic profile when

${\displaystyle \lim _{\alpha \to 0}u(r,t)=\mathrm {Re} \left\{-\sum _{n=0}^{N}{\frac {P'_{n}}{4\mu }}(R^{2}-r^{2})\,e^{in\omega t}\right\}=-\sum _{n=0}^{N}{\frac {P'_{n}}{4\mu }}(R^{2}-r^{2})\,\cos(n\omega t)\,.}$

In this case, the function is real, because the pressure and velocity waves are in phase.

Upper limit

The Bessel function at its upper limit becomes^[2]

${\displaystyle \lim _{z\to \infty }J_{0}(z\,i)={\frac {e^{z}}{\sqrt {2\pi \,z}}}\,,}$

which converges to

${\displaystyle \lim _{z\to \infty }u(r,t)=\mathrm {Re} \left\{\sum _{n=0}^{N}{\frac {i\,P'_{n}}{\rho \,n\,\omega }}\left[1-e^{\alpha \,n^{1/2}\,i^{1/2}\left({\frac {r}{R}}-1\right)}\right]e^{in\omega t}\right\}=-\sum _{n=0}^{N}{\frac {\,P'_{n}}{\rho \,n\,\omega }}\left[1-e^{\alpha \,n^{1/2}\left({\frac {r}{R}}-1\right)}\right]\sin(n\,\omega \,t)\,.}$

This is highly reminiscent of the Stokes layer on an oscillating flat plate, or the skin-depth penetration of an alternating magnetic field into an electrical conductor. On the surface ${\displaystyle u(r=R,t)=0}$, but the exponential term becomes negligible once ${\displaystyle \alpha (1-r/R)}$ becomes large, the velocity profile becomes almost constant and independent of the viscosity. Thus, the flow simply oscillates as a plug profile in time according to the pressure gradient,

${\displaystyle \rho {\frac {\partial u}{\partial t}}=-\sum _{n=0}^{N}P'_{n}\,.}$

However, close to the walls, in a layer of thickness ${\displaystyle {\mathcal {O}}(\alpha ^{-1})}$, the velocity adjusts rapidly to zero. Furthermore, the phase of the time oscillation varies quickly with position across the layer. The exponential decay of the higher frequencies is faster.

Derivation

For deriving the analytical solution of this non-stationary flow velocity profile, the following assumptions are taken:^[3][4]

• Fluid is
  incompressible and Newtonian
  ;
• Tube wall is rigid and circular;
• Motion is
  axisymmetric
  and parallel to the tube's axis;
• Boundary conditions
  are: axisymmetry at the centre, and no-slip condition on the wall;
• Pressure gradient is a periodic function that drives the fluid;
• Gravitation
  has no effect on the fluid.

Thus, the

are simplified as

${\displaystyle \rho {\frac {\partial u}{\partial t}}=-{\frac {\partial p}{\partial x}}+\mu \left({\frac {\partial ^{2}u}{\partial r^{2}}}+{\frac {1}{r}}{\frac {\partial u}{\partial r}}\right)\,}$

and

${\displaystyle {\frac {\partial u}{\partial x}}=0\,,}$

respectively. The pressure gradient driving the pulsatile flow is decomposed in Fourier series,

${\displaystyle {\frac {\partial p}{\partial x}}(t)=\sum _{n=0}^{N}P'_{n}e^{in\omega t}\,,}$

where ${\displaystyle i}$ is the imaginary number, ${\displaystyle \omega }$ is the angular frequency of the first harmonic (i.e., ${\displaystyle n=1}$), and ${\displaystyle P'_{n}}$ are the

of each harmonic ${\displaystyle n}$. Note that, ${\displaystyle P'_{0}}$ (standing for ${\displaystyle n=0}$) is the steady-state pressure gradient, whose sign is opposed to the steady-state velocity (i.e., a negative pressure gradient yields positive flow). Similarly, the velocity profile is also decomposed in Fourier series in phase with the pressure gradient, because the fluid is incompressible,

${\displaystyle u(r,t)=\sum _{n=0}^{N}U_{n}e^{in\omega t}\,,}$

where ${\displaystyle U_{n}}$ are the amplitudes of each harmonic of the periodic function, and the steady component (${\displaystyle n=0}$) is simply

${\displaystyle U_{0}=-{\frac {P'_{0}}{4\mu }}\left(R^{2}-r^{2}\right)\,.}$

Thus, the Navier-Stokes equation for each harmonic reads as

${\displaystyle i\rho n\omega U_{n}=-P'_{n}+\mu \left({\frac {\partial ^{2}U_{n}}{\partial r^{2}}}+{\frac {1}{r}}{\frac {\partial U_{n}}{\partial r}}\right)\,.}$

With the boundary conditions satisfied, the general solution of this ordinary differential equation for the oscillatory part (${\displaystyle n\geq 1}$) is

${\displaystyle U_{n}(r)=A_{n}\,J_{0}\left(\alpha \,{\frac {r}{R}}n^{1/2}\,i^{3/2}\right)+B_{n}\,Y_{0}\left(\alpha \,{\frac {r}{R}}n^{1/2}\,i^{3/2}\right)+{\frac {i\,P'_{n}}{\rho \,n\,\omega }}\,,}$

where ${\displaystyle J_{0}(\cdot )}$ is the Bessel function of first kind and order zero, ${\displaystyle Y_{0}(\cdot )}$ is the Bessel function of second kind and order zero, ${\displaystyle A_{n}}$ and ${\displaystyle B_{n}}$ are arbitrary constants, and ${\displaystyle \alpha =R\surd (\omega \rho /\mu )}$ is the

. The axisymmetric boundary condition (${\displaystyle \partial U_{n}/\partial r|_{r=0}=0}$) is applied to show that ${\displaystyle B_{n}=0}$ for the derivative of above equation to be valid, as the derivatives ${\displaystyle J_{0}'}$ and ${\displaystyle Y_{0}'}$ approach infinity. Next, the wall non-slip boundary condition (${\displaystyle U_{n}(R)=0}$) yields ${\displaystyle A_{n}=-{\frac {i\,P'_{n}}{\rho \,n\,\omega }}{\frac {1}{J_{0}\left(\alpha \,n^{1/2}\,i^{3/2}\right)}}}$. Hence, the amplitudes of the velocity profile of the harmonic ${\displaystyle n}$ becomes

${\displaystyle U_{n}(r)={\frac {i\,P'_{n}}{\rho \,n\,\omega }}\left[1-{\frac {J_{0}(\alpha \,n^{1/2}\,i^{3/2}\,{\frac {r}{R}})}{J_{0}(\alpha \,n^{1/2}\,i^{3/2})}}\right]={\frac {i\,P'_{n}}{\rho \,n\,\omega }}\left[1-{\frac {J_{0}(\Lambda _{n}\,{\frac {r}{R}})}{J_{0}(\Lambda _{n})}}\right]\,,}$

where ${\displaystyle \Lambda _{n}=\alpha \,n^{1/2}\,i^{3/2}}$ is used for simplification. The velocity profile itself is obtained by taking the

of all harmonics of the pulse,

${\displaystyle u(r,t)={\frac {P'_{0}}{4\mu }}\left(R^{2}-r^{2}\right)+\mathrm {Re} \left\{\sum _{n=1}^{N}{\frac {i\,P'_{n}}{\rho \,n\,\omega }}\left[1-{\frac {J_{0}(\Lambda _{n}\,{\frac {r}{R}})}{J_{0}(\Lambda _{n})}}\right]e^{in\omega t}\right\}\,.}$

Flow rate

Flow rate is obtained by integrating the velocity field on the cross-section. Since,

${\displaystyle {\frac {d}{dx}}\left[x^{p}J_{p}(a\,x)\right]=a\,x^{p}J_{p-1}(a\,x)\quad \Rightarrow \quad {\frac {d}{dx}}\left[x\,J_{1}(a\,x)\right]=a\,xJ_{0}(a\,x)\,,}$

then

${\displaystyle Q(t)=\iint u(r,t)\,dA=\mathrm {Re} \left\{\pi \,R^{2}\,\sum _{n=1}^{N}{\frac {i\,P'_{n}}{\rho \,n\,\omega }}\left[1-{\frac {2}{\Lambda _{n}}}{\frac {J_{1}(\Lambda _{n})}{J_{0}(\Lambda _{n})}}\right]e^{in\omega t}\right\}\,.}$

Velocity profile

To compare the shape of the velocity profile, it can be assumed that

${\displaystyle u(r,t)=f(r)\,{\frac {Q(t)}{A}}\,,}$

where

${\displaystyle f(r)={\frac {u(r,t)}{\frac {Q(t)}{A}}}=\mathrm {Re} \left\{\sum _{n=1}^{N}\left[{\frac {\Lambda _{n}\,J_{0}(\Lambda _{n})-\Lambda _{n}\,J_{0}(\Lambda _{n}\,{\frac {r}{R}})}{\Lambda _{n}\,J_{0}(\Lambda _{n})-2\,J_{1}(\Lambda _{n})}}\right]\right\}}$

is the shape function.^[5] It is important to notice that this formulation ignores the inertial effects. The velocity profile approximates a parabolic profile or a plug profile, for low or high Womersley numbers, respectively.

Wall shear stress

For straight pipes,

is

${\displaystyle \tau _{w}=\mu \left.{\frac {\partial u}{\partial r}}\right|_{r=R}\,.}$

The derivative of a Bessel function is

${\displaystyle {\frac {\partial }{\partial x}}\left[x^{-p}J_{-p}(a\,x)\right]=a\,x^{-p}J_{p+1}(a\,x)\quad \Rightarrow \quad {\frac {\partial }{\partial x}}\left[J_{0}(a\,x)\right]=-a\,J_{1}(a\,x)\,.}$

Hence,

${\displaystyle \tau _{w}=\mathrm {Re} \left\{\sum _{n=1}^{N}P'_{n}{\frac {R}{\Lambda _{n}}}{\frac {J_{1}(\Lambda _{n})}{J_{0}(\Lambda _{n})}}e^{in\omega t}\right\}\,.}$

Centre line velocity

If the pressure gradient ${\displaystyle P'_{n}}$ is not measured, it can still be obtained by measuring the velocity at the centre line. The measured velocity has only the real part of the full expression in the form of

${\displaystyle {\tilde {u}}(t)=\mathrm {Re} (u(0,t))\equiv \sum _{n=1}^{N}{\tilde {U}}_{n}\,\cos(n\,\omega \,t)\,.}$

Noting that ${\displaystyle J_{0}(0)=1}$, the full physical expression becomes

${\displaystyle u(0,t)=\mathrm {Re} \left\{\sum _{n=1}^{N}{\frac {i\,P'_{n}}{\rho \,n\,\omega }}\left[{\frac {J_{0}(\Lambda _{n})-1}{J_{0}(\Lambda _{n})}}\right]e^{in\omega t}\right\}}$

at the centre line. The measured velocity is compared with the full expression by applying some properties of complex number. For any product of complex numbers (${\displaystyle C=AB}$), the amplitude and phase have the relations ${\displaystyle |C|=|A||B|}$ and ${\displaystyle \phi _{C}=\phi _{A}+\phi _{B}}$, respectively. Hence,

${\displaystyle {\tilde {U}}_{n}=\left|{\frac {i\,P'_{n}}{\rho \,n\,\omega }}\left[{\frac {J_{0}(\Lambda _{n})-1}{J_{0}(\Lambda _{n})}}\right]\right|\quad \Rightarrow \quad P'_{n}={\tilde {U}}_{n}\left|i\,\rho \,n\,\omega \left[{\frac {J_{0}(\Lambda _{n})}{1-J_{0}(\Lambda _{n})}}\right]\right|}$

and

${\displaystyle {\tilde {\phi }}=0=\phi _{P'_{n}}+\phi _{U_{n}}\quad \Rightarrow \quad \phi _{P'_{n}}=\operatorname {phase} \left({\frac {i}{\rho \,n\,\omega }}\left[{\frac {1-J_{0}(\Lambda _{n})}{J_{0}(\Lambda _{n})}}\right]\right)\,,}$

which finally yield

${\displaystyle {\frac {1}{\rho }}{\frac {\partial p}{\partial x}}=\sum _{n=1}^{N}{\tilde {U}}_{n}\left|i\,\rho \,n\,\omega \left[{\frac {J_{0}(\Lambda _{n})}{1-J_{0}(\Lambda _{n})}}\right]\right|\,\cos \left\{n\,\omega \,t+\operatorname {phase} \left({\frac {i}{\rho \,n\,\omega }}\left[{\frac {1-J_{0}(\Lambda _{n})}{J_{0}(\Lambda _{n})}}\right]\right)\right\}\,.}$

See also

• Cardiovascular system
• Hemodynamics
• Womersley number
• Fluid hammer

References