PyrG leader
In molecular biology, the PyrG leader is a
base-pairing with a uracil (U)-rich region and the formation of an anti-terminator loop, this results in increased expression of PyrG. Under high CTP conditions the guanines are not added, the anti-terminator loop cannot form and instead a terminator loop is formed, preventing further PyrG expression.[1][2]
Further reading
- Meng Q, Turnbough CL, Switzer RL (2004). "Attenuation control of pyrG expression in Bacillus subtilis is mediated by CTP-sensitive reiterative transcription". Proc Natl Acad Sci U S A. 101 (30): 10943–10948. PMID 15252202.
- Meng Q, Switzer RL (2002). "cis-acting sequences of Bacillus subtilis pyrG mRNA essential for regulation by antitermination". J Bacteriol. 184 (23): 6734–6738. PMID 12426364.
- Jørgensen CM, Hammer K, Martinussen J (2003). "CTP limitation increases expression of CTP synthase in Lactococcus lactis". J Bacteriol. 185 (22): 6562–6574. PMID 14594829.