QRICH2

QRICH2
Identifiers
	ENSG00000129646
	ENSMUSG00000070331
	Q9H0J4
	Q3V2A7
	NM_032134; NM_001388453
	NM_001033267
	NP_115510
	NP_001028439

Glutamine-rich protein 2 is a

subcellular location of QRICH2 protein is in the nucleus.^[8]

NCBI Reference Number	Length	location	Molecular weight	PI
mRNA: NM_032134.1 Protein: NP_115510.1	mRNA: 5411 bp Protein: 1663 aa	17q25.1	180.8 kdal	6.25

Gene

QRICH2 mRNA is 5411 bp long, and its chromosomal location in human is 17q25.1. QRICH2 mRNA has 19

stem loop structure on QRICH2 mRNA because there isn't any complementary RNA sequences.^[10]

Protein

QRICH2 protein is 1663 amino acids long, and 10.9% of the amino acids are

GAPDH, NUP98 and SNAI1.^[5]

Homology [15]

paralogs

Species	Gene name	Accession(mRNA)	Length(bp)	E-value	Identity	Coverage	Location
Human	FLJ25373	AK058102	1499	0.0	99%	27%	ch7

FLJ25737 mRNA sequences^[16] perfectly match with two regions on the QRICH2 mRNA (bp 3157-4302 on QRICH2 match with bp 1-1146 on FLJ25737, bp 4998-5307 on QRICH2 match with bp 1140-1499 on FLJ25737). However, FLJ25737 locates on chromosome 7 and QRICH2 locates on chromosome 17.

Species	Protein name	Accession(Protein)	Length(aa)	E-value	Identity	Coverage	Location
Human	Spermine like protein 1	NP_001012998.2	632	6.00e-46	34%	39%	Xq21.1
Human	Protein piccolo isoform 1	NP_149015.2	5142	3.00e-10	30%	33%	7q11.23

Orthologs

Species	Common name	Divergence (Million years ago)	Accession(Protein)	Length(aa)	Identity	Coverage
Rattus norvegicus	Brown rat	92.3	XP_577148.4	1971	51%	99%
Nomascus leucogenys	Gibbon	20.4	XP_003279182.2	1768	80%	99%
Canis lupus familiaris	Dog	94.2	XP_533125.3	1936	67%	99%
Loxodonta africana	Elephant	98.7	XP_003417424.1	1973	65%	99%
Ailuropoda melanoleuca	Panda	94.2	XP_002919929.1	1903	64%	99%
Otolemur garnettii	Bushbaby	74	XP_003785524.1	1963	63%	99%
Sus scrofa	Boar	94.2	XP_003131230.1	1983	63%	99%
Cavia porcellus	Guinea pig	92.3	XP_003461498	1852	61%	99%
Felis catus	Cat	94.2	XP_003997276.1	1755	61%	98%
Papio anubis	Babbon	29	XP_003913523.1	2043	80%	97%
Gorilla gorilla	Gorilla	8.8	XP_004041087	507	99%	30%
Mus musculus	House mouse	92.3	NP_001028439.1	592	77%	30%

QRICH2 protein has well conserved orthologs in many species. The orthologous protein sequences match very well at the region where the high molecular weight Glutenin domain and ATPase involved domain is.

Function

The function of QRICH2 protein is mostly unknown. QRICH2 has been shown to belong to the common expression groups on human chromosome 17. The following genes belonged to the common expression groups on chromosome 17:

PER1. QRICH2 may also be an up-regulated gene involved in cell adhesion and cellular morphogenesis.^[18] The high expression of QRICH2 gene in testis may suggest that QRICH2 protein has some functions related to hormone production in males. QRICH2 protein has some sequence similarities with the spermidine/spermine N(1)-acetyl-like protein 1 in several species.^[15]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000129646 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070331 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Genecards: QRICH2". Genecards, The Human Gene Compendium.
^ ^a ^b "NCBI Nucleotide: QRICH2". National Center for Biotechnology Information, Nucleotide Database. 26 January 2014.
^ "NCBI Gene Expression Omnibus (GEO): QRICH2 expression in various tissues in human".
^ "PSORT II Prediction".
^ "NCBI Gene: QRICH2". National Center for Biotechnology Information, Gene Database
^ "Nucleic acid dot plot". Archived from the original on 19 August 2015. Retrieved 14 May 2013.
^ "CHOFAS tool". San Diego Supercomputer Center.
PMID 364941
.

^ "Expression data (EST profile) for QRICH2". Unigene NCBI.

^ "SOSUI, Classification and Secondary Structure Prediction". Expasy Bioinformatics Resource Portal.

^ ^a ^b "NCBI BLAST". Basic Local Alignment Search Tool.

^ "NCBI FLJ25737". NCBI Nucleotide Database. 13 September 2006.

PMID 21483740
.

PMID 22453032
.

Retrieved from "https://en.wikipedia.org/w/index.php?title=QRICH2&oldid=1187408899"

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000129646 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000070331 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[genecards-5] "Genecards: QRICH2". Genecards, The Human Gene Compendium.

[autogenerated-6] "NCBI Nucleotide: QRICH2". National Center for Biotechnology Information, Nucleotide Database. 26 January 2014.

[NCBI_Gene_Expression_Omnibus(GEO):_QRICH2_expression_in_various_tissues_in_human-7] "NCBI Gene Expression Omnibus (GEO): QRICH2 expression in various tissues in human".

[PSORT_II_Prediction-8] "PSORT II Prediction".

[NCBI_GENE:_QRICH2-9] "NCBI Gene: QRICH2". National Center for Biotechnology Information, Gene Database

[Nucleic_acid_dot_plot-10] "Nucleic acid dot plot". Archived from the original on 19 August 2015. Retrieved 14 May 2013.

[SDSC_Biological_workbench-11] "CHOFAS tool". San Diego Supercomputer Center.

[pmid364941-12] PMID 364941
.

[13] "Expression data (EST profile) for QRICH2". Unigene NCBI.

[14] "SOSUI, Classification and Secondary Structure Prediction". Expasy Bioinformatics Resource Portal.

[blast.ncbi-15] "NCBI BLAST". Basic Local Alignment Search Tool.

[16] "NCBI FLJ25737". NCBI Nucleotide Database. 13 September 2006.

[pmid21483740-17] PMID 21483740
.

[pmid22453032-18] PMID 22453032
.

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