Rule of three (statistics)

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Comparison of the rule of three to the exact binomial one-sided confidence interval with no positive samples

In

human subjects, and no adverse event
is recorded. From the rule of three, it can be concluded with 95% confidence that fewer than 1 person in 500 (or 3/1500) will experience an adverse event. By symmetry, for only successes, the 95% confidence interval is [1−3/n,1].

The rule is useful in the interpretation of

statistical power. The rule of three applies well beyond medical research, to any trial done n times. If 300 parachutes are randomly tested and all open successfully, then it is concluded with 95% confidence that fewer than 1 in 100 parachutes with the same characteristics (3/300) will fail.[1]

Derivation

A 95% confidence interval is sought for the probability p of an event occurring for any randomly selected single individual in a population, given that it has not been observed to occur in n Bernoulli trials. Denoting the number of events by X, we therefore wish to find the values of the parameter p of a binomial distribution that give Pr(X = 0) ≤ 0.05. The rule can then be derived[2] either from the Poisson approximation to the binomial distribution, or from the formula (1−p)n for the probability of zero events in the binomial distribution. In the latter case, the edge of the confidence interval is given by Pr(X = 0) = 0.05 and hence (1−p)n = .05 so n ln(1–p) = ln .05 ≈ −2.996. Rounding the latter to −3 and using the approximation, for p close to 0, that ln(1−p) ≈ −p (Taylor's formula), we obtain the interval's boundary 3/n.

By a similar argument, the numerator values of 3.51, 4.61, and 5.3 may be used for the 97%, 99%, and 99.5% confidence intervals, respectively, and in general the upper end of the confidence interval can be given as , where is the desired confidence level.

Extension

The

unimodal distributions with finite variance beyond just the binomial distribution, and gives a way to change the factor 3 if a different confidence is desired. Chebyshev's inequality removes the assumption of unimodality at the price of a higher multiplier (about 4.5 for 95% confidence). Cantelli's inequality
is the one-tailed version of Chebyshev's inequality.

See also

Notes

  1. three standard deviations
    ] as definitely significant" – and claimed it for his new journal of significance testing, Biometrika. Even Darwin late in life seems to have fallen into the confusion. (Ziliak and McCloskey, 2008, p. 26; parenthetic gloss in original)

  2. ^ "Professor Mean" (2010) "Confidence interval with zero events", The Children's Mercy Hospital. Retrieved 2013-01-01.

References

  • Eypasch, Ernst; Rolf Lefering; C. K. Kum; Hans Troidl (1995). "Probability of adverse events that have not yet occurred: A statistical reminder". BMJ. 311 (7005): 619–620.
    PMID 7663258
    .
  • Hanley, J. A.; A. Lippman-Hand (1983). "If nothing goes wrong, is everything alright?". JAMA. 249 (13): 1743–5. .