SCHEMBL19952957

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SCHEMBL19952957
Identifiers
  • 4-[3-(4-cyclopentyloxyphenyl)-1,2,4-oxadiazol-5-yl]phenol
JSmol)
  • C1CCC(C1)OC2=CC=C(C=C2)C3=NOC(=N3)C4=CC=C(C=C4)O
  • InChI=1S/C19H18N2O3/c22-15-9-5-14(6-10-15)19-20-18(21-24-19)13-7-11-17(12-8-13)23-16-3-1-2-4-16/h5-12,16,22H,1-4H2
  • Key:LTWUHRPUKBTFBZ-UHFFFAOYSA-N

SCHEMBL19952957 is an

Clostridium difficile as it not only kills active bacteria, but also inhibits the germination of the dormant spores which can otherwise often lead to persistent infections that repeatedly recur upon cessation of antibiotic treatment. While it is still only being researched in animals at this stage, this dual action is a significant advance over existing antibiotics, and it is likely that drugs from this class may be developed as new medications for the treatment of antibiotic resistant infections in humans.[1][2][3][4]

See also

References

  1. ^ US 10662164, Chang M, Mobashery S, Spink E, Ding D, Testero S, Leemans E, Boudreau M, "Non-beta lactam antibiotics", issued 26 May 2020, assigned to University of Notre Dame. 
  2. ^ US 11168062, Chang M, Mobashery S, Ding D, "Compounds for the treatment of Clostridium difficile infection", issued 9 November 2021, assigned to University of Notre Dame. 
  3. S2CID 258565494
    .
  4. ^ Yirka B (9 May 2023). "Dual-action antibiotic found that kills C. difficile, preventing reinfections". Medical Xpress.


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