Sensing of phage-triggered ion cascades

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Sensing of phage-triggered ion cascades (SEPTIC)[1][2] is a prompt bacterium identification method based on fluctuation-enhanced sensing in fluid medium. The advantages of SEPTIC are the specificity and speed (needs only a few minutes) offered by the characteristics of phage infection, the sensitivity due to fluctuation-enhanced sensing, and durability originating from the robustness of phages. An idealistic SEPTIC device may be as small as a pen and maybe able to identify a library of different bacteria within a few minutes measurement window.

The mechanism

SEPTIC utilizes

1/f noise spectrum. In order to have a high sensitivity, a DC electrical field attracts the infected bacteria (which are charged due to ion imbalance) to the electrode with the relevant polarization.[5]

Advantages

The advantages of SEPTIC are the specificity and speed (needs only a few minutes) offered by the characteristics of phage infection, the sensitivity due to fluctuation-enhanced sensing, and durability originating from the robustness of phages. An idealistic SEPTIC device may be as small as a pen and maybe able to identify a library of different bacteria within a few minutes measurement window.

History

The SEPTIC concept was first conceived by

Sergey M. Bezrukov (NIH), and Bob Biard.[7] A new, related scheme, BIPIF,[6] that has recently been conceived and analyzed by Laszlo B. Kish and Gabor Schmera (SPAWAR, United States Navy
) utilizes the AC impedance fluctuations at related arrangements, and it promises higher sensitivity and less dependence on the electrodes.

References

  1. ^ "The SEPTIC patent description in PATENTSCOPE".
  2. ^ a b "Feature article on SEPTIC in The Economist magazine". 14 April 2005.
  3. ^ "M. Dobozi-King, S. Seo, J.U. Kim, R. Young, M. Cheng, L.B. Kish, "Rapid detection and identification of bacteria: SEnsing of Phage-Triggered Ion Cascade (SEPTIC)", Journal of Biological Physics and Chemistry 5 (2005) 3–7" (PDF).
  4. ^ "L.B. Kish, M. Cheng, J.U. Kim, S. Seo, M.D. King, R. Young, A. Der, G. Schmera, "Estimation of the detection limits of the phage-invasion based identification of bacteria", Fluctuation and Noise Letters 5 (2005) L105-L108" (PDF).
  5. ^ a b "J.R. Biard, L.B. Kish, "Enhancing the sensitivity of the SEPTIC bacterium sensing method by concentrating the phage-infected bacteria via DC electrical current", Fluctuation and Noise Letters 5 (2005) L153-L158" (PDF).
  6. ^
    arXiv:1004.0147 [physics.ins-det
    ].
  7. ^ "Featuring SEPTIC in Nanotechwire".

External links

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