Sodium calcium edetate
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Sodium calcium edetate (sodium calcium EDTA), also known as edetate calcium disodium among other names, is a medication primarily used to treat lead poisoning,[2] including both short-term and long-term lead poisoning.[3] Sodium calcium edetate came into medical use in the United States in 1953.[3]
Chelation agent
Sodium calcium edetate is in the
It works by binding to a number of heavy metals, which renders them almost inert and allows them to leave the body in the urine.[3]Edetate disodium (Endrate) is a different formulation which does not have the same effects.[3]
Medical use
Sodium calcium edetate's primary use is to treat lead poisoning,[2] for which it is an alternative to succimer.[3] It is given by
slow injection into a vein or into a muscle.[2]
For
lead encephalopathy sodium calcium edetate is typically used together with dimercaprol.[3]
It may also be used to treat plutonium poisoning.[5]
It does not appear to be useful for poisoning by tetra-ethyl lead.[3]
Side effects
Common side effects include pain at the site of injection.
History
Sodium calcium edetate came into medical use in the United States in 1953.[3] It is on the World Health Organization's List of Essential Medicines.[6]
References
- FDA. Retrieved 22 October 2023.
- ^ ISBN 9789241547659.
- ^ a b c d e f g h i j k "Edetate Calcium Disodium". The American Society of Health-System Pharmacists. Archived from the original on 16 January 2017. Retrieved 8 January 2017.
- ISBN 9788185790121. Archivedfrom the original on 16 January 2017.
- ISBN 9780203485071. Archivedfrom the original on 16 January 2017.
- hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.