Spectator ligand

In

polydentate, such that the M-spectator ensemble is inert kinetically. Although they do not participate in reactions of the metal, spectator ligands influence the reactivity of the metal center to which they are bound. These ligands are sometimes referred to as ancillary ligands. ^[2]

Several different classes of ligand exist that can be considered spectator ligands. A few examples include

1,2-bis(diphenylphosphino)ethane ligands (dppe). Varying the substituents on the spectator ligands greatly influences the solubility, stability, electronic, and steric properties of the metal complex. In the area of platinum-based antineoplastic agents, spectator (and nonspectator) ligands greatly affect efficacy.^[3]

Idealized structure of a Tp ligand bound to a metal center ML_n. Tp⁻ is a spectator ligand in this complex.

Ball-and-stick model of [PdCl₂(dppe)]. Dppe is a spectator ligand in this complex.

References

ISBN 9781119951438
.

^ Michael D. Fryzuk, T. S. Haddad, David J. Berg and Steven J. Rettig "Phosphine complexes of the early metals and the lanthanoids" Pure & Appl. Chem., Vol. 63, No. 6, pp. 845-850, 1991

doi:10.1021/acs.chemrev.5b00597

Retrieved from "https://en.wikipedia.org/w/index.php?title=Spectator_ligand&oldid=1134695324"

[trofimenko-1] ISBN 9781119951438
.

[2] Michael D. Fryzuk, T. S. Haddad, David J. Berg and Steven J. Rettig "Phosphine complexes of the early metals and the lanthanoids" Pure & Appl. Chem., Vol. 63, No. 6, pp. 845-850, 1991

[3] doi:10.1021/acs.chemrev.5b00597

[2]

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