Talk:Antibody-dependent cellular cytotoxicity

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This article was the subject of a Wiki Education Foundation-supported course assignment, between 24 March 2020 and 29 April 2020. Further details are available on the course page. Peer reviewers: Alexis Skipper, ErinNHolman.

Above undated message substituted from

talk) 14:28, 16 January 2022 (UTC)[reply
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comment

third line down in this article (http://en.wikipedia.org/wiki/Antibody-dependent_cellular_cytotoxicity) there is a hyperlink 'ADCC' in parentheses which actually links the viewer to the wikipedia article on the Abu Dhabi Combat Club (http://en.wikipedia.org/wiki/ADCC). i thought it would be most relevant to remove this hyperlink:). good day.— Preceding unsigned comment added by 85.101.10.195 (talk • contribs) 16:10, 6 September 2006 (UTC)[reply]

Changed introduction

I made the changes because I think it was inappropriate to introduce the article describing 'cell mediated immunity'. Furthermore, I don't think that ADCC can really be classified as its own 'mechanism' of cell mediated immunity, as all three of the mentioned mechanisms (T cell, NK cell, ADCC) use the same 'mechanism' per say (i.e. granule exocytosis, perforin, granzymes), its just a question of different mechanisms of recognition.

Cacofonie 15:43, 11 January 2007 (UTC)[reply]


I stated that the most common Fc on NK is CD16 because they have been shown to express CD32c too. Andy Rosenthal 07:02, 15 May 2007 (UTC)[reply]

Proper name of the article

Should it be

Antibody-Dependent Cell-Mediated Cytotoxicity or Antibody-dependent cellular cytotoxicity
? Could someone who know clarify that?

I just added a reference whose abstract uses "antibody-dependent cell-mediated cytotoxicity." More important, I just linked to this article using that phrase. However, Pub-med had 1285 hits on "antibody-dependent cell-mediated cytotoxicity", whereas "antibody-dependent cellular cytotoxicity" had 2077 (retrieved 2009 Dec. 18). That ratio is not huge, but I think you have a point. I sure don't want to do the changes manually, though. Is there a bot to do it, including internal links to this article? C4dn (talk) 04:27, 19 December 2009 (UTC)[reply]

A quick Google search of "Antibody-dependent cellular cytotoxicity" yielded 261,000 hits while "Antibody-Dependent Cell-Mediated Cytotoxicity" yielded only 185,000 hits. More telling is the number of scholarly articles: Only 1 for "Antibody-Dependent Cell-Mediated Cytotoxicity" and 32,300 for "Antibody-dependent cellular cytotoxicity". Unless there is great objection, I feel the title ought to be changed/ — Preceding unsigned comment added by 2601:E:D180:3810:6493:9BAF:F374:1D80 (talk) 22:16, 2 February 2015 (UTC)[reply]

This is biology. This is language. This is *not* about google searches and pubmed hits and it BETTER NOT BE ABOUT BOTS scanning things bots cannot understand. The point is what does "ADCC" best represent, and the current title that uses "cell-mediated cytotoxicity" is the correct one. It is more precise in terms of the underlying mechanisms. It also has an implication that distinguishes it from other mechanisms. (A bot could not know that.) The alternative of "cellular cytotoxicity" is less precise and lacks that implication. That alternative is not wrong; it's not as good. It's kind of stupid because it's redundant -- cytotoxicity by definition is cellular -- unless it's not, in which case it's ambiguous. The prevalence of its use does not reflect its superiority but most likely comes from many factors that have nothing to do with science per se -- I suspect the preference comes from little more than people wanting to match the abbreviation more closely ("A-DCC") than using the more precise but more unwieldy term that has an additional hyphen in it ("A-DC-MC"). Look, this is how science actually works... people do stuff for all kinds of reasons and names stick because some one got there first, or some one was more famous, or some people liked the sound better, or whatever. The sociology of science leads to things like this all the time which is more often trivial and unheralded but occasionally reaches the public like in the famous example of "NMR" being changed to "MRI" because physicians thought the public would be afraid of the word "nuclear". Wikipedia is intended to inform, not to play blind semantic games. If you want readers to understand what ADCC is, do not introduce ambiguity, DO NOT CHANGE THE TITLE, keep it as it is.Lapabc (talk) 13:24, 28 April 2017 (UTC)[reply]

sources of information

Much of the material on this page comes from Fry, Mitchell. Essential Biochemistry for Medicine. An attribution to this source may be appropriate. — Preceding unsigned comment added by 98.250.107.205 (talk) 17:14, 14 February 2012 (UTC)[reply]

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