Talk:cGMP-specific phosphodiesterase type 5

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The section on PDE5 mechanism of action needs to be rewritten. As it stands, the section focuses on the mechanism of PDE5 inhibitors, and there is already a page for that. The wiki entry on the molecular pathology of pulmonary hypertension has a much better summary, including a figure.Clayt85 (talk) 20:51, 6 August 2015 (UTC)[reply]

Is "very effective" really a peacock term when it comes to drugs? PDE-5 inhibitors are highly selective compared to other drugs that inhibit the same enzyme, and they DO work well.

There is no mention of contraindication of PDE5 inhibitors with nitrates causing hypotension, also I'm not sure that it mentions vision problems, maybe consider adding a Adverse Reactions section.

"PDE5 activity is modulated by a rapidly reversible redox switch"
Wikipedia needs an article about redox regulation of enzymes and other proteins such as transcription factors. --JWSchmidt 00:36, 1 December 2005 (UTC)[reply]

"PDE5 is an enzyme that accepts cGMP and breaks it down" Informal language like this is not appropriate for an encyclopedia

I came to find out what the actual reaction it catalyzes is; what is the breakdown product of cGMP? — Preceding unsigned comment added by 206.12.36.11 (talk) 00:19, 11 July 2013 (UTC)[reply]

Some of the grammar of this article clearly needs correcting, preferably by someone who actually knows the subject. That will help the rest of us to understand the article!

A PDE5 inhibitor that is significantly more potent and selective than zaprinast (an early PDE5 inhibitor) and comparable in its PDE inhibitory properties [[??[ to ] IS  ??]] sildenafil (Viagra, 1998), a drug recently approved for the treatment of male erectile dysfunction.

...

PDE5 is an enzyme that accepts cGMP and breaks it down. The kinetics of binding [3H]sildenafil and [3H]tadalafil to the catalytic site of PDE5. ??Possibly refers to missing image??

....

The mechanism of action of E4021 on both the nonactivated and activated forms of rod PDE6 main verb?? because both states are relevant to understanding how PDE5-selective inhibitors may alter signal transduction pathways in photoreceptor cells.

Jezzabr 18:10, 23 December 2005 (UTC)[reply]

Hi.

I was wondering : you guys write that "with viagra on board", an erection is the consequence of the non-degradation of the enzyme. What about if I don't have to take viagras to get an erection ? Is this enzyme still responsible for it, and how ? I thought erections were due to an excess of blood entering the penis. How is this related to CGMP enzymes ?

thanks. King mike 08:15, 17 May 2006 (UTC)[reply]

Hi, The mechanism by which cGMP induces erection is explained on the page for Viagra. Maybe it would be good to duplicate that section here in some way?

I'd really suggest someone go through this page and return it to its scientific baseline, it reads like marketing material for Viagra ("Pfizer needed a chemical...", "When a man takes a Viagra® pill...", "The dilemma: which drug to choose and why.", etc). It also seems that someone tried to add a bunch of images that are now broken. 70.35.227.160 09:30, 5 October 2006 (UTC)[reply]